Nakagawa Tsuyoshi, Oda Goshi, Kikuchi Akifumi, Saito Toshifumi, Fujioka Tomoyuki, Kubota Kazunori, Mori Mio, Onishi Iichiro, Uetake Hiroyuki
Department of Breast Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyou-ku, Tokyo, 113-8519 Japan.
Department of Colorectal Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Int Cancer Conf J. 2020 Nov 14;10(1):91-94. doi: 10.1007/s13691-020-00456-w. eCollection 2021 Jan.
The accuracy of modern imaging techniques for the diagnosis of peritoneal carcinomatosis is poor. A breast cancer patient with a high serum CA15-3 level did not receive a definitive diagnosis of peritoneal dissemination by imaging examination and then underwent laparoscopy. Pathological examination showed peritoneal dissemination of breast cancer, but the biological markers were different from the primary lesion: ER(-), PgR(-), and Her2:3 +. T-DM1 therapy was very effective, and her systemic symptoms disappeared. Since biomarkers of metastatic lesions may sometimes change, laparoscopic biopsy is very important and useful.
现代成像技术对腹膜癌转移的诊断准确性较差。一名血清CA15-3水平较高的乳腺癌患者经影像学检查未得到腹膜播散的确切诊断，随后接受了腹腔镜检查。病理检查显示为乳腺癌腹膜播散，但生物学标志物与原发灶不同：雌激素受体（ER）阴性、孕激素受体（PgR）阴性，人表皮生长因子受体2（Her2）：3+。曲妥珠单抗-美坦新偶联物（T-DM1）治疗非常有效，她的全身症状消失。由于转移灶的生物标志物有时可能会发生变化，因此腹腔镜活检非常重要且有用。
