格列齐特在基质系统中的释放特性。
Release characteristics of gliclazide in a matrix system.
作者信息
Tatlisoz Mehmet Melih, Demirturk Esra, Canpolat Cetin
机构信息
Biomedical Engineering Department, Faculty of Engineering, Cukurova University, 01250 Adana, Turkey.
Department of Pharmaceutics Technology, Faculty of Pharmacy, Cukurova University, 01250 Adana, Turkey.
出版信息
In Silico Pharmacol. 2021 Jan 11;9(1):12. doi: 10.1007/s40203-020-00068-5. eCollection 2021.
In this study, the release characteristics of gliclazide in a polymeric matrix system, which is used for controlled drug release purposes, are conducted experimentally and numerically. A code using the finite element method predicting the drug release behavior of gliclazide matrix system in an aqueous medium is developed. The parameters having significant importance in drug release kinetics, such as structure factor, the slab's size and shape are varied systematically. The consistent reduction in the solid drug during the dissolution process is evaluated. The numerical data agree well with the experimental results. Therefore, the controlled drug release of gliclazide is accurately modeled by the present numerical code. The results imply that the porosity of the matrix system has the most significant effect on the drug dissolution rate. The reduction in the tablet's diameter and utilization of cylindrical slab geometry increases the speed of the drug dissolution in the aqueous medium.
在本研究中，对用于控释目的的格列齐特在聚合物基质系统中的释放特性进行了实验和数值研究。开发了一种使用有限元方法预测格列齐特基质系统在水性介质中药物释放行为的代码。在药物释放动力学中具有重要意义的参数，如结构因子、平板的尺寸和形状，被系统地改变。评估了溶解过程中固体药物的持续减少情况。数值数据与实验结果吻合良好。因此，本数值代码准确地模拟了格列齐特的控释过程。结果表明，基质系统的孔隙率对药物溶解速率影响最为显著。片剂直径的减小和圆柱形平板几何形状的使用提高了药物在水性介质中的溶解速度。
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