Stanford M R, Robbins J
Department of Immunology, UMDS, St Thomas's Campus, London.
Br J Ophthalmol. 1988 Feb;72(2):88-96. doi: 10.1136/bjo.72.2.88.
Experimental posterior uveitis was induced by the inoculation of retinal S-antigen into black hooded Lister rats. The time course of the disease was monitored by electroretinography (ERG), and the ERG changes were correlated with clinical signs and underlying pathological damage. The ERG became supernormal in the third week after inoculation, with some loss of temporal resolution (lowered ERG flicker fusion frequency), though the disease was not clinically manifest at this time and histological examination was normal. The ERG became subnormal after 21 days as clinical signs of disease began to appear. This subnormality was associated with focal photoreceptor necrosis, the degree of destruction being proportional to the reduction in the ERG. The ERG recovered with resolution of disease in most cases, though return to control values was uncommon. We suggest that the initial supernormal ERG reflects an underlying biochemical change mediated by the action of anti retinal S-antigen antibodies.
通过向黑色头巾利斯特大鼠眼内接种视网膜S抗原诱发实验性后葡萄膜炎。用电视网膜图（ERG）监测疾病的时间进程，并将ERG变化与临床体征和潜在的病理损伤相关联。接种后第三周ERG变得超常，颞分辨力有所丧失（ERG闪烁融合频率降低），尽管此时疾病尚无临床表现且组织学检查正常。随着疾病临床体征开始出现，21天后ERG变得低于正常。这种低于正常与局灶性光感受器坏死相关，破坏程度与ERG降低成正比。在大多数情况下，随着疾病消退ERG恢复，尽管恢复到对照值的情况并不常见。我们认为，最初的超常ERG反映了由抗视网膜S抗原抗体作用介导的潜在生化变化。
