Tang Ran, Xian Dehai, Xu Jixiang, Peng Huiling, Pan Shihong, Zhong Jianqiao
Department of Dermatology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Department of Anatomy, Southwest Medical University, Luzhou 646000, China.
Biomed Res Int. 2021 Jan 2;2021:5695378. doi: 10.1155/2021/5695378. eCollection 2021.
Hemangioma, the most common benign vascular tumor, not only affects the appearance and psychology but also has a life-threatening potential. It is considered that clonal vascular endothelial cell proliferation and excessive angiogenesis are responsible for hemangioma pathogenesis, in which abnormal cytokines/pathways are closely implicated, primarily including high expression of hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) as well as their downstream pathways, especially phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt). These further stimulate the migration and proliferation of vascular endothelial cells and promote the formation of new vessels, ultimately leading to the occurrence and development of hemangioma. Proanthocyanidins are naturally active substance from plants and fruits. They possess multiple functions like antiproliferation, antiangiogenesis, and antitumor. It has been demonstrated that proanthocyanidins effectively work in various diseases via inhibiting the expression of various factors, e.g., HIF-1, VEGF, PI3K, and Akt. Considering the pathogenesis of hemangioma and the effect of proanthocyanidins, we hold a hypothesis that proanthocyanidins would be applied in hemangioma via downregulating cytokine/pathway expression, suppressing vascular cell proliferation and arrest abnormal angiogenesis. Taken together, proanthocyanidins may be a potential novel way for the treatment of hemangioma.
血管瘤是最常见的良性血管肿瘤，不仅影响外观和心理，还具有危及生命的可能性。人们认为克隆性血管内皮细胞增殖和过度血管生成是血管瘤发病机制的原因，其中异常细胞因子/信号通路密切相关，主要包括缺氧诱导因子-1（HIF-1）和血管内皮生长因子（VEGF）的高表达及其下游信号通路，尤其是磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）。这些进一步刺激血管内皮细胞的迁移和增殖，促进新血管的形成，最终导致血管瘤的发生和发展。原花青素是来自植物和水果的天然活性物质。它们具有多种功能，如抗增殖、抗血管生成和抗肿瘤。已经证明原花青素通过抑制各种因子如HIF-1、VEGF、PI3K和Akt的表达在各种疾病中有效发挥作用。考虑到血管瘤的发病机制和原花青素的作用，我们提出一种假设，即原花青素可通过下调细胞因子/信号通路表达、抑制血管细胞增殖和阻止异常血管生成来应用于血管瘤治疗。综上所述，原花青素可能是一种潜在的治疗血管瘤的新方法。
