T1ρ磁共振成像值作为评估肝纤维化严重程度的潜在标志物：一项初步研究。
T1ρ magnetic resonance imaging value as a potential marker to assess the severity of liver fibrosis: A pilot study.
作者信息
Suyama Yohsuke, Tomita Kengo, Soga Shigeyoshi, Kuwamura Hiroshi, Murakami Wakana, Hokari Ryota, Shinmoto Hiroshi
机构信息
Department of Radiology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.
Department of Gastroenterology and Hepatology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.
出版信息
Eur J Radiol Open. 2021 Jan 7;8:100321. doi: 10.1016/j.ejro.2021.100321. eCollection 2021.
PURPOSE
Assessment of liver fibrosis is essential for the management of liver disease. Although liver biopsy is the gold-standard modality for the diagnosis of liver fibrosis, it has some limitations. Thus, other methods are required to overcome the disadvantages of a liver biopsy. T1ρ magnetic resonance imaging (MRI) values are potential biomarkers for liver cirrhosis. This study aimed to assess the relationship between T1ρ MRI values and liver fibrosis severity by measuring the correlation between T1ρ values and shear wave elastography (SWE) values, which are routinely used for the diagnosis of liver fibrosis.
METHODS
T1ρ imaging and SWE values were obtained from four healthy volunteers and 16 patients with chronic liver disease. The regions of interest on MR images were drawn and matched with those of the right liver lobe on SWE images.
RESULTS
The mean T1ρ values of the right liver lobe correlated positively with the mean SWE values (Pearson's correlation coefficient: 0.783; p < 0.0001; 95 % confidence interval: 0.623-0.880).
CONCLUSION
The mean T1ρ values of the right liver lobe may be correlated with the severity of liver fibrosis.
目的
评估肝纤维化对于肝病的管理至关重要。尽管肝活检是诊断肝纤维化的金标准方法，但它存在一些局限性。因此，需要其他方法来克服肝活检的缺点。T1ρ磁共振成像（MRI）值是肝硬化的潜在生物标志物。本研究旨在通过测量T1ρ值与常规用于诊断肝纤维化的剪切波弹性成像（SWE）值之间的相关性，评估T1ρ MRI值与肝纤维化严重程度之间的关系。
方法
从4名健康志愿者和16名慢性肝病患者中获取T1ρ成像和SWE值。在MR图像上绘制感兴趣区域，并与SWE图像上右肝叶的区域进行匹配。
结果
右肝叶的平均T1ρ值与平均SWE值呈正相关（Pearson相关系数：0.783；p < 0.0001；95%置信区间：0.623 - 0.880）。
结论
右肝叶的平均T1ρ值可能与肝纤维化的严重程度相关。
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