Quintessence Int. 2021 Mar 3;52(4):340-346. doi: 10.3290/j.qi.b912637.
Oral squamous cell carcinoma (OSCC) is an extremely rare occurrence during pregnancy. OSCC accounts for less than 2% of all malignancies in pregnant women, with an average mortality rate of 36%. Understanding the features of this tumor during pregnancy is important; however, the paucity of reports in the literature makes this challenging. Case presentation: The following is a case presentation of a woman who was diagnosed with SCC of the tongue (TSCC) at 13 weeks gestation. The article also provides a review of the literature of TSCC affecting pregnant women aged 30 years and under. Conclusion: Although OSCC in young women of reproductive age is rare, recent literature suggests an increased risk for this age group. The rarity of OSCC in pregnancy may potentially lead to low clinical index of suspicion, misdiagnosis, and delay in treatment. Additionally, treatment modalities, prognosis, and the long-term impact on the developing fetus are not well established, due to rarity of OSCC in pregnancy. Further studies to identify specific etiologic factors are needed to establish the association of OSCC with pregnancy, aid in prevention, and improve treatment and outcome.
口腔鳞状细胞癌（OSCC）在怀孕期间极为罕见。OSCC 在孕妇所有恶性肿瘤中所占比例不到 2%，平均死亡率为 36%。了解怀孕期间这种肿瘤的特征很重要；然而，文献中报告的病例很少，这使得这一问题具有挑战性。
以下是一例在妊娠 13 周时被诊断为舌鳞状细胞癌（TSCC）的女性病例介绍。本文还对影响 30 岁及以下孕妇的 TSCC 文献进行了回顾。
尽管年轻生育年龄女性的 OSCC 罕见，但最近的文献表明该年龄组的风险增加。OSCC 在妊娠中的罕见性可能导致临床怀疑指数低、误诊和治疗延迟。此外，由于 OSCC 在妊娠中罕见，因此治疗方式、预后以及对发育中胎儿的长期影响尚未得到很好的确定。需要进一步的研究来确定特定的病因因素，以确定 OSCC 与妊娠的关联，帮助预防，并改善治疗和结果。
