Koliada A Iu, Gel'shteĭn V I, Kobliakov V A
Biull Eksp Biol Med. 1988 Feb;105(2):198-200.
The content of cytochrome P-450 has been measured in primary hepatomas induced by diethylnitrosamine. As a rule, the enzyme content in hepatomas was decreased, as compared to normal liver and tumor-affected liver, but some hepatomas contained cytochrome P-450 in greater amount than normal tissue. Aroclor 1254 induced an increase in cytochrome P-450 content, which was identical in hepatomas, normal liver and tumor-affected liver. The dependence of hepatoma morphology on cytochrome P-450 content was not detected.
已对二乙基亚硝胺诱导的原发性肝癌中细胞色素P - 450的含量进行了测定。通常，与正常肝脏和患瘤肝脏相比，肝癌中的该酶含量降低，但一些肝癌所含细胞色素P - 450的量比正常组织更多。多氯联苯混合物1254可诱导细胞色素P - 450含量增加，在肝癌、正常肝脏和患瘤肝脏中增加情况相同。未检测到肝癌形态与细胞色素P - 450含量之间的相关性。
