Desfossés Charles Y, Blier Pierre
The Royal's Institute of Mental Health Research, 1145 Carling Avenue, Ottawa, ON, K1Z 7K4, Canada.
The Royal's Institute of Mental Health Research, 1145 Carling Avenue, Ottawa, ON, K1Z 7K4, Canada - Department of Psychiatry, University of Ottawa, 1145 Carling Avenue, Ottawa, ON, K1Z 7K4, Canada - Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada.
Med Sci (Paris). 2021 Jan;37(1):27-34. doi: 10.1051/medsci/2020256. Epub 2021 Jan 25.
Major depression is a frequent and disabling disorder. Despite great developments in the field of psychopharmacology since the 1950's, delayed onset of action and treatment resistance to current pharmacological options, such as serotonin reuptake inhibitors, remain a therapeutic challenge. The recent discovery of the rapid antidepressant action of ketamine, an NMDA (N-methyl-D-aspartate) receptor antagonist, has brought a revolution to this field. This paper presents a comprehensive review of the clinical research on the antidepressant properties of ketamine as well as its presumed mechanisms of action.
重度抑郁症是一种常见且致残的疾病。自20世纪50年代以来，尽管精神药理学领域取得了巨大进展，但目前的药物治疗方案，如5-羟色胺再摄取抑制剂，起效延迟和治疗抵抗仍然是一个治疗挑战。N-甲基-D-天冬氨酸（NMDA）受体拮抗剂氯胺酮具有快速抗抑郁作用，这一最新发现给该领域带来了一场革命。本文全面综述了氯胺酮抗抑郁特性的临床研究及其推测的作用机制。
