[揭示脑胶质细胞作用的新技术]

[New technologies to unveil the role of brain glial cells].

作者信息

Hemonnot-Girard Anne-Laure, Ben Haim Lucile, Escartin Carole, Hirbec Hélène

机构信息

IGF, Univ Montpellier, CNRS, Inserm, Montpellier, France.

Université Paris-Saclay, CEA, CNRS, MIRCen (Molecular Imaging Research Center), Laboratoire des maladies neurodégénératives, 92265, Fontenay-aux-Roses, France.

出版信息

Med Sci (Paris). 2021 Jan;37(1):59-67. doi: 10.1051/medsci/2020253. Epub 2021 Jan 25.

DOI:10.1051/medsci/2020253

PMID:33492220

Abstract

Brain function relies on complex interactions between neurons and different types of glial cells, such as astrocytes, microglia and oligodendrocytes. The relatively young field of "gliobiology" is thriving. Thanks to various technical innovations, it is now possible to address challenging biological questions on glial cells and unravel their multiple roles in brain function and dysfunction.

摘要

脑功能依赖于神经元与不同类型神经胶质细胞（如星形胶质细胞、小胶质细胞和少突胶质细胞）之间的复杂相互作用。相对年轻的“神经胶质生物学”领域正在蓬勃发展。得益于各种技术创新，现在有可能解决有关神经胶质细胞的具有挑战性的生物学问题，并揭示它们在脑功能和功能障碍中的多种作用。