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基于大型中心 10 年经验的 817 例病例分析:机器人胃癌根治术后并发症的发生率及危险因素。

Incidence and risk factors of postoperative complications after robotic gastrectomy for gastric cancer: an analysis of 817 cases based on 10-year experience in a large-scale center.

机构信息

Department of General Surgery, Center for Minimally Invasive Gastrointestinal Surgery, Southwest Hospital, Third Military Medical University, 30 Gao Tan Yan Road, Chongqing, 400038, China.

出版信息

Surg Endosc. 2021 Dec;35(12):7034-7041. doi: 10.1007/s00464-020-08218-8. Epub 2021 Jan 25.

Abstract

BACKGROUND

In this study, we investigated the incidence and risk factors for postoperative complications after robotic gastrectomy (RG) in patients with gastric cancer.

METHODS

A total of 817 patients who underwent RG for gastric cancer between March 2010 and August 2019 were analyzed retrospectively. Postoperative complications were categorized according to the Clavien-Dindo classification, and possible risk factors were evaluated.

RESULTS

Among 817 patients who underwent RG, overall, severe, local and systemic complication rates were 13.8, 4.2, 7.0 and 6.9%, respectively. Multivariable analysis revealed that an age of 70 years or older (P < 0.001) and multiorgan resection (P = 0.031) were independent risk factors for the occurrence of overall complications. Multivariable analysis showed that an age of 70 years or older (P = 0.005) and surgeons' experience ≤ 25 cases (P = 0.004) were independent risk factors for severe complications. Regarding local complications, an age of 70 years or older (P < 0.001), multiorgan resection (P = 0.010) and surgeons' experience ≤ 25 cases (P = 0.005) were identified as independent risk factors. An age of 70 years or older (P < 0.001), a BMI of 25 or higher (P = 0.045) and the presence of comorbidity (P = 0.029) were identified as independent risk factors for systemic complications.

CONCLUSIONS

The present study demonstrated that RG is a safe and feasible procedure for the treatment of gastric cancer, and it has an acceptable postoperative morbidity. Elderly patients and insufficient surgeon experience were two major risk factors for the occurrence of complications following RG. We suggest that surgeons choose patients in good condition during their RG learning phase to reduce learning-associated morbidity.

摘要

背景

本研究旨在探讨机器人胃癌根治术后(RG)并发症的发生率和危险因素。

方法

回顾性分析 2010 年 3 月至 2019 年 8 月间接受 RG 治疗的 817 例胃癌患者。根据 Clavien-Dindo 分类对术后并发症进行分类,并评估可能的危险因素。

结果

817 例接受 RG 的患者中,总体、严重、局部和全身并发症发生率分别为 13.8%、4.2%、7.0%和 6.9%。多变量分析显示,年龄 70 岁或以上(P<0.001)和多器官切除(P=0.031)是总体并发症发生的独立危险因素。多变量分析显示,年龄 70 岁或以上(P=0.005)和术者经验≤25 例(P=0.004)是严重并发症发生的独立危险因素。局部并发症中,年龄 70 岁或以上(P<0.001)、多器官切除(P=0.010)和术者经验≤25 例(P=0.005)是独立危险因素。年龄 70 岁或以上(P<0.001)、BMI 为 25 或更高(P=0.045)和并存疾病(P=0.029)是全身并发症的独立危险因素。

结论

本研究表明,RG 是治疗胃癌安全可行的方法,术后并发症发病率可接受。老年患者和术者经验不足是 RG 术后并发症发生的两个主要危险因素。我们建议术者在 RG 学习阶段选择身体状况良好的患者,以降低学习相关的发病率。

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