Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Department of Graduate School, Zunyi Medical University, Zunyi, People's Republic of China.
DNA Cell Biol. 2021 Feb;40(2):316-331. doi: 10.1089/dna.2020.6136. Epub 2021 Jan 25.
Lung adenocarcinoma (LUAD) acts as the representative histological subtype regarding lung cancer, and its mortality and morbidity remain high. Therefore, more therapeutic targets are needed. Insulin-like growth factor 2 messenger RNA-binding proteins (IGF2BPs), a class of RNA-binding proteins, including , , and , are considered to be the "reader" of N6-methyladenosine (m6A) methylation and remarkably affects cancer occurrence and development. Studies have shown that has prognostic potential in multiple public databases compared with other members of the IGF2BPs family. This research aims to use the expression data of in multiple cohorts to explore the expression as well as prognostic significance of in LUAD. Based on the six datasets from the Oncomine database, LUAD tissue presented obviously higher expression relative to normal tissue. In the three cohorts of The Cancer Genome Atlas (TCGA), Gene expression profiling interactive analysis, and Gene Expression Omnibus, was abnormally highly expressed in LUAD, and it could lead to a weaker prognosis ( < 0.05). The cohort from National Cancer Center of China (NCC) verified the prognostic value of , and the high expression could be remarkably related to gender, tumor length, differentiation, and T stage ( < 0.05). Cox regression analysis of TCGA and NCC cohorts consistently showed that expression could serve for independently predicting the prognosis of LUAD patients ( < 0.05). Ten hallmark pathways with significant enrichment were identified. is abnormally highly expressed in LUAD tissue, and can lead to worse overall survival. In summary, may be an oncogene and potential prognostic biomarker of LUAD.
肺腺癌（LUAD）是肺癌的代表性组织学亚型，其死亡率和发病率仍然很高。因此，需要更多的治疗靶点。胰岛素样生长因子 2 信使 RNA 结合蛋白（IGF2BPs）是一类 RNA 结合蛋白，包括 、 、 和 ，被认为是 N6-甲基腺苷（m6A）甲基化的“阅读器”，并显著影响癌症的发生和发展。研究表明，与 IGF2BPs 家族的其他成员相比， 在多个公共数据库中具有预后潜力。本研究旨在使用多个队列的 表达数据来探讨 LUAD 中 的表达及其预后意义。基于 Oncomine 数据库中的六个数据集，LUAD 组织的 表达明显高于正常组织。在三个 TCGA 队列、基因表达谱交互分析和基因表达综合数据库中， 异常高表达于 LUAD，且可能导致预后较差（<0.05）。来自中国国家癌症中心（NCC）的队列验证了 的预后价值，高 表达与性别、肿瘤长度、分化和 T 分期显著相关（<0.05）。TCGA 和 NCC 队列的 Cox 回归分析一致表明， 表达可独立预测 LUAD 患者的预后（<0.05）。确定了 10 个具有显著富集的标志性通路。 在 LUAD 组织中异常高表达，并导致总体生存较差。总之， 可能是 LUAD 的致癌基因和潜在的预后生物标志物。
