Department of Animal Science, Kazi Nazrul University, Asansol, West Bengal, India.
Post Graduate Department of Zoology, A.B.N. Seal College, Cooch Behar, West Bengal, India.
Food Chem Toxicol. 2021 Mar;149:112007. doi: 10.1016/j.fct.2021.112007. Epub 2021 Jan 23.
Consistent gathering of immunotoxic substances on earth is a serious global issue affecting people under pathogenic stress. Organophosphates are among such hazardous compounds that are ubiquitous in nature. They fuel oxidative stress to impair antiviral immune response in living entities. Aside, organophosphates promote cytokine burst and pyroptosis in broncho-alveolar chambers leading to severe respiratory ailments. At present, we witness COVID-19 outbreak caused by SARS-CoV-2. Infection triggers cytokine storm coupled with inflammatory manifestations and pulmonary disorders in patients. Since organophosphate-exposure promotes necroinflammation and respiratory troubles hence during current pandemic situation, additional exposure to such chemicals can exacerbate inflammatory outcome and pulmonary maladies in patients, or pre-exposure to organophosphates might turn-out to be a risk factor for compromised immunity. Fortunately, antioxidants alleviate organophosphate-induced immunosuppression and hence under co-exposure circumstances, dietary intake of antioxidants would be beneficial to boost immunity against SARS-CoV-2 infection.
地球上免疫毒性物质的持续积累是一个严重的全球问题，影响着处于致病压力下的人群。有机磷化合物就是此类危险化合物之一，它们在自然界中无处不在。它们引发氧化应激，损害生物体的抗病毒免疫反应。此外，有机磷化合物会促进细胞因子爆发和肺泡腔中的细胞焦亡，导致严重的呼吸道疾病。目前，我们正目睹由 SARS-CoV-2 引起的 COVID-19 爆发。感染会引发细胞因子风暴，并伴有炎症表现和肺部疾病。由于有机磷暴露会促进坏死性炎症和呼吸问题，因此在当前的大流行情况下，额外接触此类化学物质会加剧患者的炎症后果和肺部疾病，或者预先接触有机磷化合物可能成为免疫受损的一个风险因素。幸运的是，抗氧化剂可以缓解有机磷引起的免疫抑制，因此在共同暴露的情况下，饮食中摄入抗氧化剂有益于增强对 SARS-CoV-2 感染的免疫力。
