Department of Psychiatry, Nepean Hospital, Penrith, NSW, Australia; University of Sydney, Faculty of Medicine and Health, Sydney Medical School, Nepean Clinical School, Discipline of Psychiatry, Penrith, NSW, Australia.
Discipline of Clinical Psychology, Graduate School of Health, University of Technology, Sydney, Ultimo, NSW, Australia; School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
Psychiatry Res. 2021 Mar;297:113721. doi: 10.1016/j.psychres.2021.113721. Epub 2021 Jan 14.
The aims of this study were to investigate the prevalence of anxiety and related disorders (e.g., obsessive-compulsive disorder [OCD]) and major depressive disorder (MDD) at any time during pregnancy and during each pregnancy trimester and ascertain the proportions of women with an onset of these disorders during pregnancy. Several questionnaires and the Mini International Neuropsychiatric Interview were administered to 200 women at each pregnancy trimester. Complete data were obtained from 148 participants. The most prevalent anxiety disorder at any time during pregnancy was panic disorder (PD), followed by generalised anxiety disorder (GAD) and OCD. Unlike all the other disorders, the prevalence rates of OCD increased steadily from the first to the third trimester. Approximately one half of women with OCD and about one third of women with PD, GAD and MDD at any time during pregnancy had an onset of these disorders during pregnancy. Pregnancy may be a risk factor for an onset of OCD and to a lesser extent, for an onset of PD, GAD and MDD. Absence of remission of OCD during pregnancy despite treatment may suggest treatment resistance of OCD at this time. These findings have implications for recognition, prevention and treatment of anxiety disorders during pregnancy.
本研究旨在调查怀孕期间任何时候以及每个妊娠期间焦虑症及相关障碍（如强迫症[OCD]）和重度抑郁症（MDD）的患病率，并确定这些障碍在怀孕期间发病的女性比例。在每个妊娠期间，我们向 200 名女性发放了几种问卷和迷你国际神经精神访谈。从 148 名参与者那里获得了完整的数据。怀孕期间任何时候最常见的焦虑症是恐慌症（PD），其次是广泛性焦虑症（GAD）和 OCD。与所有其他疾病不同，OCD 的患病率从第一孕期到第三孕期稳步上升。大约一半的 OCD 患者，以及大约三分之一的 PD、GAD 和 MDD 患者在怀孕期间任何时候都出现了这些疾病。怀孕可能是 OCD 发病的一个危险因素，而对 PD、GAD 和 MDD 的发病影响较小。尽管进行了治疗，但怀孕期间 OCD 仍未缓解，这可能表明此时 OCD 存在治疗抵抗。这些发现对怀孕期间焦虑症的识别、预防和治疗具有重要意义。
