Bergman W, Ruiter D J, Scheffer E, van Vloten W A
Department of Dermatology, University Medical Center, Leiden, The Netherlands.
Cancer. 1988 Apr 15;61(8):1660-6. doi: 10.1002/1097-0142(19880415)61:8<1660::aid-cncr2820610825>3.0.co;2-x.
In a double-blind study a correlation was found between the histologically assessed degree of nevomelanocytic atypia in 58 dysplastic nevi (DN) and the presence of two markers associated with malignant transformation. The markers included a marked expression of histocompatibility locus Class I antigens on nevomelanocytes (P less than 0.01) and abnormalities in the nuclear DNA content as measured by DNA cytophotometry (P = 0.01). Both markers were present in most of the markedly atypical DN, in about half of the moderately atypical DN, and in less than 30% of the mildly atypical DN. These findings suggest that a DN with marked or moderate melanocytic atypia indicates a premalignant condition and identifies a patient at risk for melanoma.
在一项双盲研究中，发现58个发育异常痣（DN）的组织学评估的痣黑素细胞异型程度与两个与恶性转化相关的标志物的存在之间存在相关性。这些标志物包括痣黑素细胞上组织相容性I类抗原的明显表达（P小于0.01）以及通过DNA细胞光度法测量的核DNA含量异常（P = 0.01）。这两个标志物在大多数明显异型的DN中存在，在约一半的中度异型DN中存在，而在轻度异型DN中不到30%存在。这些发现表明，具有明显或中度黑素细胞异型的DN表明是一种癌前状态，并识别出有患黑色素瘤风险的患者。
