Technical Research Center, China Tobacco Sichuan Industrial Co., Ltd, Chengdu, China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
Nat Prod Res. 2022 Jul;36(14):3644-3650. doi: 10.1080/14786419.2021.1876047. Epub 2021 Jan 26.
A new acridone alkaloid, reticarcidone A (1), decorated with an oxygenated isopentenyl group between C-1 and C-2, was isolated from the leaves of Blanco, together with nine known acridone alkaloids (2-10) and fifteen flavones compounds (11-25). The structure of those compounds were confirmed by analysis of comprehensive 1D and 2D NMR, and MS data. Reticarcidone A (1) was the first pyrano[2,3-a]acridone isolated from the genus . Some of these compounds showed moderated cytotoxicity against the five human tumor cell lines MCF-7, SMMC-7721, HL-60, A549 and SW480.
从 Blanco 的叶子中分离得到了一个新的吖啶酮生物碱 reticarcidone A（1），其在 C-1 和 C-2 之间有一个含氧异戊烯基。同时还分离得到了 9 个已知的吖啶酮生物碱（2-10）和 15 个黄酮类化合物（11-25）。这些化合物的结构通过综合 1D 和 2D NMR 和 MS 数据分析得到了确认。Reticarcidone A（1）是首次从属中分离得到的吡喃并[2,3-a]吖啶酮。其中一些化合物对五种人肿瘤细胞系 MCF-7、SMMC-7721、HL-60、A549 和 SW480 表现出中等的细胞毒性。
