Department of Pathology and Laboratory Medicine, Emory University Hospital, 1364 Clifton Road NE, Atlanta, GA 30322, USA; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Egleston Hospital, 1405 Clifton Rd, Atlanta, GA 30322, USA.
Department of Pathology and Laboratory Medicine, Emory University Hospital, 1364 Clifton Road NE, Atlanta, GA 30322, USA; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Egleston Hospital, 1405 Clifton Rd, Atlanta, GA 30322, USA.
Clin Lab Med. 2021 Mar;41(1):15-34. doi: 10.1016/j.cll.2020.10.002. Epub 2020 Dec 23.
Transfusion of red blood cells, platelets, and fresh frozen plasma in neonatal patients has not been well characterized in the literature, with guidelines varying greatly between institutions. However, anemia and thrombocytopenia are highly prevalent, especially in preterm neonates. When transfusing a neonatal patient, clinicians must take into consideration physiologic differences, gestational and postnatal age, congenital disorders, and maternal factors while weighing the risks and benefits of transfusion. This review of existing literature summarizes current evidence-based neonatal transfusion guidelines and highlights areas of current ongoing research and those in need of future studies.
新生儿患者的红细胞、血小板和新鲜冷冻血浆的输注在文献中尚未得到很好的描述，不同机构的指南差异很大。然而，贫血和血小板减少症非常普遍，尤其是早产儿。在给新生儿患者输血时，临床医生必须考虑到生理差异、胎龄和出生后年龄、先天性疾病和产妇因素，同时权衡输血的风险和益处。对现有文献的回顾总结了目前基于证据的新生儿输血指南，并强调了当前正在进行的研究领域以及需要未来研究的领域。
