细胞间黏附分子-1的一级结构显示了免疫球蛋白超基因家族成员与整合素超基因家族成员之间的相互作用。

Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families.

作者信息

Staunton D E, Marlin S D, Stratowa C, Dustin M L, Springer T A

机构信息

Laboratory of Membrane Immunochemistry, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115.

出版信息

Cell. 1988 Mar 25;52(6):925-33. doi: 10.1016/0092-8674(88)90434-5.

DOI:10.1016/0092-8674(88)90434-5

PMID:3349522

Abstract

Intercellular adhesion molecule 1 (ICAM-1) is a 90 kd inducible surface glycoprotein that promotes adhesion in immunological and inflammatory reactions. ICAM-1 is a ligand of lymphocyte function-associated antigen-1 (LFA-1), an alpha beta complex that is a member of the integrin family of cell-cell and cell-matrix receptors. ICAM-1 is encoded by an inducible 3.3 kb mRNA. The amino acid sequence specifies an integral membrane protein with an extracellular domain of 453 residues containing five immunoglobulin-like domains. Highest homology is found with neural cell adhesion molecule (NCAM) and myelin-associated glycoprotein (MAG), which also contain five Ig-like domains. NCAM and MAG are nervous system adhesion molecules, but unlike ICAM-1, NCAM is homophilic. The ICAM-1 and LFA-1 interaction is heterophilic and unusual in that it is between members of the immunoglobulin and intergrin families. Unlike other integrin ligands, ICAM-1 does not contain an RGD sequence.

摘要

细胞间黏附分子1（ICAM-1）是一种90千道尔顿的可诱导性表面糖蛋白，在免疫和炎症反应中促进黏附作用。ICAM-1是淋巴细胞功能相关抗原-1（LFA-1）的配体，LFA-1是一种αβ复合物，属于细胞间和细胞与基质受体的整合素家族成员。ICAM-1由一种可诱导的3.3 kb信使核糖核酸编码。氨基酸序列确定了一种整合膜蛋白，其细胞外结构域有453个残基，包含五个免疫球蛋白样结构域。与神经细胞黏附分子（NCAM）和髓磷脂相关糖蛋白（MAG）具有最高同源性，它们也含有五个免疫球蛋白样结构域。NCAM和MAG是神经系统黏附分子，但与ICAM-1不同，NCAM是同嗜性的。ICAM-1和LFA-1的相互作用是异嗜性的，且不同寻常，因为它发生在免疫球蛋白和整合素家族成员之间。与其他整合素配体不同，ICAM-1不包含RGD序列。