Centre of Excellence for Rehabilitation Medicine, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht University and De Hoogstraat Rehabilitation, Utrecht, The Netherlands.
University of Groningen, University Medical Centre Groningen, Centre for Rehabilitation, Groningen, The Netherlands.
Spinal Cord. 2021 Mar;59(3):328-335. doi: 10.1038/s41393-020-00599-w. Epub 2021 Jan 25.
Cross-sectional.
To examine the association between post-traumatic stress disorder (PTSD) symptoms and pain intensity, taking symptoms of anxiety and depression into account within persons with spinal cord injury (SCI).
Persons with SCI, who visited a Dutch rehabilitation centre between 2005 and 2010, were invited to complete a survey.
PTSD symptoms were measured with the Trauma Screening Questionnaire (TSQ), pain intensity with an 11-point Numerical Rating Scale (NRS), and symptoms of anxiety and depression with the Hospital Anxiety and Depression Scale (HADS). To determine associations between PTSD symptoms and pain intensity, linear regression analyses were performed. Confounding variables representing anxiety and depression were added to the final model.
In total, 175 participants (55.8% traumatic, 29.1% complete) were included (response rate of 31.7%). Of them, 11.4% had clinically relevant symptoms of probable PTSD (TSQ score ≥ 6) 69.8% experienced moderate to severe pain levels (NRS ≥ 4), 14.9% had symptoms of anxiety and 20.8% symptoms of depression (HADS scores ≥ 11). Levels of PTSD symptoms were strongly associated with symptoms of anxiety (0.54) and depression (0.49). Bivariate analyses showed a moderate significant association (0.30) between PTSD symptoms and pain intensity. This association became small (0.10) when anxiety and depression comorbidity were factored into the final regression model.
No independent association between PTSD symptoms and pain intensity was shown when adjusted for anxiety and depression. Results of this study suggest the usefulness of screening for PTSD in persons with SCI (regardless of injury cause or type/level) who score high on symptoms of anxiety/depression.
横断面研究。
在脊髓损伤(SCI)患者中,考虑到焦虑和抑郁症状,检查创伤后应激障碍(PTSD)症状与疼痛强度之间的关联。
2005 年至 2010 年间,邀请参观荷兰康复中心的 SCI 患者完成一项调查。
使用创伤筛查问卷(TSQ)测量 PTSD 症状,使用 11 点数字评分量表(NRS)测量疼痛强度,使用医院焦虑和抑郁量表(HADS)测量焦虑和抑郁症状。为了确定 PTSD 症状与疼痛强度之间的关联,进行了线性回归分析。将代表焦虑和抑郁的混杂变量添加到最终模型中。
共纳入 175 名参与者(55.8%为创伤性,29.1%为完全性)(响应率为 31.7%)。其中,11.4%有临床相关的可能 PTSD 症状(TSQ 得分≥6),69.8%有中到重度疼痛水平(NRS≥4),14.9%有焦虑症状,20.8%有抑郁症状(HADS 得分≥11)。PTSD 症状水平与焦虑症状(0.54)和抑郁症状(0.49)高度相关。双变量分析显示 PTSD 症状与疼痛强度之间存在中度显著关联(0.30)。当将焦虑和抑郁共病纳入最终回归模型时,该关联变得较小(0.10)。
在调整焦虑和抑郁后,未显示 PTSD 症状与疼痛强度之间存在独立关联。本研究结果表明,在焦虑/抑郁症状评分较高的 SCI 患者(无论损伤原因或类型/水平如何)中,筛查 PTSD 是有用的。