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骨水泥植入综合征在骨水泥髋关节半髋关节置换术中的持续风险。

Bone cement implantation syndrome in cemented hip hemiarthroplasty-a persistent risk.

机构信息

Department of Trauma, Hand, and Reconstructive Surgery, University Hospital Frankfurt/Main, Theodor-Stern Kai 7, 60590, Frankfurt am Main, Germany.

Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt/Main, Theodor-Stern Kai 7, 60590, Frankfurt am Main, Germany.

出版信息

Eur J Trauma Emerg Surg. 2022 Apr;48(2):721-729. doi: 10.1007/s00068-020-01587-8. Epub 2021 Jan 26.

Abstract

BACKGROUND

Every year, ~ 210,000 initial implantations of hip endoprostheses are carried out in Germany alone. The "bone cement implantation syndrome" (BCIS) is considered a severe peri- and early-postoperative complication when implanting cemented prostheses. The origin of the BCIS and its impact on the clinical outcome are still uncertain. This study investigates the clinical progression after BCIS cases in patients with cemented hemiarthroplasty. Risk factors for the occurrence of BCIS are evaluated.

MATERIAL AND METHODS

Clinical data of all patients with a proximal femur fracture and which received a cemented hemiarthroplasty within a period of 9.5 years have been collected. BCIS (+) patients and BCIS (-) patients were compared with respect to their demographics and clinical outcome. Risk factors for the development of BCIS were identified.

RESULTS

A total of 208 patients could be included with complete data sets. The mean age was 81.1 ± 10.0 years. Overall, 37% of the patients showed symptoms of BCIS. In comparison to BCIS (-) patients there was a significantly higher rate of cardiovascular complications (27.3% vs. 13.7%, p = 0.016) and a higher in-hospital mortality rate (15.6% vs. 4.6%, p = 0.006) in BCIS (+) patients. Age, absence of a femoral borehole and ASA status were identified as statistically significant risk factors of BCIS.

CONCLUSION

BCIS is frequently observed and in some cases severe complication. The therapy is exclusively symptomatic; identifying preventional measures might reduce the occurrence of BCIS.

摘要

背景

仅在德国,每年就有约 21 万例髋关节假体的初次植入。在植入骨水泥假体时,“骨水泥植入综合征(BCIS)”被认为是一种严重的围手术期和早期术后并发症。BCIS 的起源及其对临床结果的影响仍不确定。本研究调查了接受骨水泥半髋关节置换术的患者中发生 BCIS 后的临床进展。评估了发生 BCIS 的危险因素。

材料和方法

收集了 9.5 年内患有股骨近端骨折并接受骨水泥半髋关节置换术的所有患者的临床数据。比较了 BCIS(+)患者和 BCIS(-)患者的人口统计学和临床结果。确定了发生 BCIS 的危险因素。

结果

共纳入 208 例具有完整数据集的患者。平均年龄为 81.1±10.0 岁。总体而言,37%的患者出现了 BCIS 症状。与 BCIS(-)患者相比,BCIS(+)患者的心血管并发症发生率(27.3%比 13.7%,p=0.016)和住院死亡率(15.6%比 4.6%,p=0.006)显著更高。年龄、无股骨钻孔和 ASA 状态被确定为 BCIS 的统计学显著危险因素。

结论

BCIS 是一种常见的且在某些情况下严重的并发症。治疗方法仅限于对症治疗;确定预防措施可能会降低 BCIS 的发生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a278/9001528/002983d47fd2/68_2020_1587_Fig1_HTML.jpg

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