Institute for Nanotechnology Innovation, Department of Chemistry, Rhodes University, Makhanda 6140, South Africa.
Dalton Trans. 2021 Feb 16;50(6):2177-2182. doi: 10.1039/d0dt03958f.
A new readily-synthesized Sn(iv) tetraarylchlorin with thien-2-yl substituents (SnC) has been prepared and fully characterized by various spectroscopic techniques and its photophysical and photochemical properties, such as the singlet oxygen quantum yield (ΦΔ), fluorescence quantum yield (ΦF), triplet lifetime (τT) and photostability, have been evaluated. SnC has an unusually high ΦΔ value of 0.89 in DMF. Studies on the photodynamic activity against MCF-7 breast cancer cells exhibited a very low IC50 value of 0.9 μM and high phototoxicity (dark versus light) indices of >27.8 after irradiation with a 660 nm Thorlabs LED (280 mW cm-2). The results demonstrate that Sn(iv) tetraarylchlorins of this type are suitable candidates for further in-depth PDT studies.
一种新的易于合成的具有噻吩-2-基取代基的锡（IV）四芳基氯（SnC）已被制备，并通过各种光谱技术对其进行了充分的表征，评估了其光物理和光化学性质，如单线态氧量子产率（ΦΔ）、荧光量子产率（ΦF）、三重态寿命（τT）和光稳定性。SnC 在 DMF 中具有异常高的 ΦΔ 值 0.89。对 MCF-7 乳腺癌细胞的光动力活性研究表明，在 660nm Thorlabs LED（280mWcm-2）照射下，其 IC50 值非常低，为 0.9μM，且光毒性（暗与光）指数>27.8。结果表明，此类锡（IV）四芳基氯是进一步深入 PDT 研究的合适候选物。
