Schwartz E, Friedman E, Mouallem M, Farfel Z
Department of Medicine, Sheba Medical Center, Tel Aviv University School of Medicine, Tel Hashomer, Israel.
Clin Cardiol. 1988 Jan;11(1):53-4. doi: 10.1002/clc.4960110118.
A 65-year-old male with diabetes, hypertension, and mild renal failure developed dizziness and syncope one week after starting clonidine 0.45 mg/day. A continuous ECG recording revealed sinus bradycardia, nodal rhythm, and multiple episodes of sinus arrest lasting up to 4.5 seconds. Upon discontinuation of clonidine, serial continuous ECG recordings revealed gradual decrease in the number and duration of the sinus arrest episodes, until their complete disappearance shortly after the third day off clonidine. This report shows that clonidine may cause a concentration-dependent sinus node dysfunction in addition to the atrioventricular (AV) node abnormalities previously ascribed to it.
一名65岁男性，患有糖尿病、高血压和轻度肾衰竭，在开始服用可乐定0.45毫克/天后一周出现头晕和晕厥。连续心电图记录显示窦性心动过缓、结性心律以及多次窦性停搏发作，持续时间长达4.5秒。停用可乐定后，连续系列心电图记录显示窦性停搏发作的次数和持续时间逐渐减少，直到在停用可乐定第三天后不久完全消失。本报告表明，可乐定除了先前认为的可导致房室（AV）结异常外，还可能引起浓度依赖性窦房结功能障碍。
