Department of Neuroscience and Padova Neuroscience Center, University of Padova, 35128 Padova, Italy; Padova Neuroscience Center, PNC, 35131 Padova, Italy.
Department of Neuroscience, Imaging and Clinical Sciences - and ITAB, Institute for Advanced Biomedical Technologies, G. d'Annunzio University of Chieti-Pescara, 66100 Chieti, Italy.
Neuroimage. 2021 Apr 15;230:117781. doi: 10.1016/j.neuroimage.2021.117781. Epub 2021 Jan 23.
The functional architecture of the resting brain, as measured with the blood oxygenation level-dependent functional connectivity (BOLD-FC), is slightly modified during task performance. In previous work, we reported behaviorally relevant BOLD-FC modulations between visual and dorsal attention regions when subjects performed a visuospatial attention task as compared to central fixation (Spadone et al., 2015). Here we use magnetoencephalography (MEG) in the same group of subjects to identify the electrophysiological correlates of the BOLD-FC modulation found in our previous work. While BOLD-FC topography, separately at rest and during visual attention, corresponded to neuromagnetic Band-Limited Power (BLP) correlation in the alpha and beta bands (8-30 Hz), BOLD-FC modulations evoked by performing the visual attention task (Spadone et al. 2015) did not match any specific oscillatory band BLP modulation. Conversely, following the application of an orthogonal spatial decomposition that identifies common inter-subject co-variations, we found that attention-rest BOLD-FC modulations were recapitulated by multi-spectral BLP-FC components. Notably, individual variability of alpha connectivity between Frontal Eye Fields and visual occipital regions, jointly with decreased interaction in the Visual network, correlated with visual discrimination accuracy. In summary, task-rest BOLD connectivity modulations match multi-spectral MEG BLP connectivity.
静息态大脑的功能架构，通过血氧水平依赖功能连接（BOLD-FC）进行测量，在任务执行过程中会略有改变。在之前的工作中，当受试者执行视觉空间注意任务而不是中央注视时，我们报告了视觉和背侧注意区域之间与行为相关的 BOLD-FC 调制（Spadone 等人，2015）。在这里，我们在同一组受试者中使用脑磁图（MEG）来识别我们之前工作中发现的 BOLD-FC 调制的电生理相关性。虽然 BOLD-FC 地形图，分别在静息和视觉注意时，与 alpha 和 beta 波段（8-30 Hz）的神经磁带宽限制功率（BLP）相关，但执行视觉注意任务引起的 BOLD-FC 调制与任何特定的振荡带 BLP 调制都不匹配。相反，在应用一种可以识别共同的跨主体变异性的正交空间分解后，我们发现注意力-休息状态的 BOLD-FC 调制可以通过多光谱 BLP-FC 成分来重现。值得注意的是，额叶眼区和视觉枕区之间的 alpha 连接的个体变异性，以及视觉网络中相互作用的减少，与视觉辨别准确性相关。总之，任务-休息 BOLD 连接调制与多光谱 MEG BLP 连接调制匹配。
