Clinical Exercise and Respiratory Physiology Laboratory, Department of Kinesiology and Physical Education, McGill University, Montréal, Canada; UniSA: Allied Health and Human Performance, Innovation, Implementation And Clinical Translation in Health, University of South Australia, Adelaide, Australia.
Montreal Chest Institute, McGill University Health Center Research Institute, McGill University, Montréal, Québec, Canada.
Respir Physiol Neurobiol. 2021 May;287:103619. doi: 10.1016/j.resp.2021.103619. Epub 2021 Jan 23.
This study compared the multidimensional breathlessness response to incremental cardiopulmonary cycle exercise testing (CPET) in people with chronic obstructive pulmonary disease (COPD; n = 14, aged 69 ± 9 years, forced expiratory volume in 1-sec = 54 ± 16 % predicted) and healthy older (OA) (n = 35, aged 68 ± 5 years) and younger (YA) (n = 19, aged 28 ± 8 years) adults. Participants performed CPET and successively rated overall breathlessness intensity, unsatisfied inspiration, breathing too shallow, work/effort of breathing, and breathlessness-related unpleasantness, fear, and anxiety using the 0-10 Borg scale. At any given percent predicted peak minute ventilation, people with COPD rated all breathlessness sensations higher than OA and YAs, who were similar. Most between group differences disappeared when examined in relation to inspiratory reserve volume, except people with COPD reported higher levels of unsatisfied inspiration and breathing too shallow (vs YA), and breathlessness-related fear and anxiety (vs OA and YAs). Multidimensional ratings of breathlessness sensations during CPET provides further insight into differences in exertional symptom perceptions among people with COPD and without COPD.
本研究比较了慢性阻塞性肺疾病（COPD；n = 14，年龄 69 ± 9 岁，1 秒用力呼气量 = 54 ± 16%预计值）患者与健康老年人（OA）（n = 35，年龄 68 ± 5 岁）和年轻人（YA）（n = 19，年龄 28 ± 8 岁）在递增心肺循环运动测试（CPET）中多维呼吸困难反应。参与者使用 0-10 Borg 量表对整体呼吸困难强度、吸气不足、呼吸过浅、呼吸费力和呼吸困难相关的不愉快、恐惧和焦虑进行评分。在给定的预计峰值分钟通气量的任何百分比下，COPD 患者的所有呼吸困难感觉评分均高于 OA 和 YA，而 OA 和 YA 之间的评分相似。当根据吸气储备量进行检查时，大多数组间差异消失，但 COPD 患者报告的吸气不足和呼吸过浅（与 YA 相比）以及呼吸困难相关的恐惧和焦虑（与 OA 和 YA 相比）水平更高。CPET 期间呼吸困难感觉的多维评分进一步深入了解了 COPD 患者和非 COPD 患者在运动症状感知方面的差异。
