• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Non-coding RNA crosstalk with nuclear receptors in liver disease.非编码 RNA 与核受体在肝脏疾病中的相互作用。
Biochim Biophys Acta Mol Basis Dis. 2021 May 1;1867(5):166083. doi: 10.1016/j.bbadis.2021.166083. Epub 2021 Jan 24.
2
The long and the small collide: LncRNAs and small heterodimer partner (SHP) in liver disease.长短碰撞：长链非编码 RNA 和小异二聚体伴侣 (SHP) 在肝脏疾病中的作用。
Mol Cell Endocrinol. 2021 May 15;528:111262. doi: 10.1016/j.mce.2021.111262. Epub 2021 Mar 26.
3
Nuclear Receptors as Therapeutic Targets in Liver Disease: Are We There Yet?核受体作为肝脏疾病的治疗靶点：我们做到了吗？
Annu Rev Pharmacol Toxicol. 2016;56:605-626. doi: 10.1146/annurev-pharmtox-010715-103209.
4
Decoding hepatocarcinogenesis from a noncoding RNAs perspective.从非编码 RNA 的角度解码肝癌发生。
J Cell Physiol. 2023 Sep;238(9):1982-2009. doi: 10.1002/jcp.31076. Epub 2023 Jul 14.
5
Noncoding RNAs and the control of signalling via nuclear receptor regulation in health and disease.非编码RNA与健康和疾病中通过核受体调控进行的信号传导控制
Best Pract Res Clin Endocrinol Metab. 2015 Aug;29(4):529-43. doi: 10.1016/j.beem.2015.07.003. Epub 2015 Jul 14.
6
Non-Coding RNAs in Neurological and Neuropsychiatric Disorders: Unraveling the Hidden Players in Disease Pathogenesis.非编码 RNA 在神经和神经精神疾病中的作用：揭示疾病发病机制中的潜在参与者。
Cells. 2024 Jun 19;13(12):1063. doi: 10.3390/cells13121063.
7
Extracellular Vesicles as Delivery Vehicles for Non-Coding RNAs: Potential Biomarkers for Chronic Liver Diseases.细胞外囊泡作为非编码 RNA 的递送载体：慢性肝病的潜在生物标志物。
Biomolecules. 2024 Feb 26;14(3):277. doi: 10.3390/biom14030277.
8
Non-coding RNAs in hepatitis C-induced hepatocellular carcinoma: dysregulation and implications for early detection, diagnosis and therapy.非编码 RNA 在丙型肝炎病毒诱导的肝细胞癌中的作用：失调及其对早期检测、诊断和治疗的影响。
World J Gastroenterol. 2013 Nov 28;19(44):7836-45. doi: 10.3748/wjg.v19.i44.7836.
9
Non-coding RNA-based regulation of inflammation.基于非编码RNA的炎症调节
Semin Immunol. 2022 Jan;59:101606. doi: 10.1016/j.smim.2022.101606. Epub 2022 Jun 10.
10
Long noncoding RNAs-a new dimension in the molecular architecture of the bile acid/FXR pathway.长链非编码 RNA——胆汁酸/FXR 通路分子结构的新维度。
Mol Cell Endocrinol. 2021 Apr 5;525:111191. doi: 10.1016/j.mce.2021.111191. Epub 2021 Feb 1.

引用本文的文献

1
The Role of miRNAs and Epigenetic Factors in Non-Alcoholic Fatty Liver Disease - a Systematic Review.微小RNA和表观遗传因素在非酒精性脂肪性肝病中的作用——一项系统综述
Curr Health Sci J. 2025 Jan-Mar;51(1):37-52. doi: 10.12865/CHSJ.51.01.04. Epub 2025 Mar 31.
2
Geniposidic Acid Targeting FXR "S332 and H447" Mediated Conformational Change to Upregulate CYPs and miR-19a-3p to Ameliorate Drug-Induced Liver Injury.京尼平苷酸靶向FXR“S332和H447”介导的构象变化以上调细胞色素P450酶和miR-19a-3p以改善药物性肝损伤。
Adv Sci (Weinh). 2025 Apr;12(15):e2409107. doi: 10.1002/advs.202409107. Epub 2025 Feb 25.
3
Recent Advances in miRNA-Based Therapy for MASLD/MASH and MASH-Associated HCC.miRNA 治疗 MASLD/MASH 和与 MASH 相关 HCC 的最新进展。
Int J Mol Sci. 2024 Nov 14;25(22):12229. doi: 10.3390/ijms252212229.
4
Circulating microRNA panels in subjects with metabolic dysfunction-associated steatotic liver disease after following a 2-year dietary intervention.在进行为期2年的饮食干预后，代谢功能障碍相关脂肪性肝病患者的循环微RNA谱。
J Endocrinol Invest. 2025 Apr;48(4):987-1003. doi: 10.1007/s40618-024-02499-9. Epub 2024 Nov 16.
5
Long Non-Coding RNAs, Nuclear Receptors and Their Cross-Talks in Cancer-Implications and Perspectives.长链非编码RNA、核受体及其在癌症中的相互作用——影响与展望
Cancers (Basel). 2024 Aug 22;16(16):2920. doi: 10.3390/cancers16162920.
6
Endocrine nuclear receptors and long non‑coding RNAs reciprocal regulation in cancer (Review).内分泌核受体与长非编码 RNA 在癌症中的相互调控（综述）。
Int J Oncol. 2024 Jan;64(1). doi: 10.3892/ijo.2023.5595. Epub 2023 Dec 1.
7
Western diet-induced shifts in the maternal microbiome are associated with altered microRNA expression in baboon placenta and fetal liver.西方饮食导致的母体微生物群变化与狒狒胎盘和胎儿肝脏中微小RNA表达的改变有关。
Front Clin Diabetes Healthc. 2022;3. doi: 10.3389/fcdhc.2022.945768. Epub 2022 Sep 8.
8
Cholesterol Metabolism in Chronic Kidney Disease: Physiology, Pathologic Mechanisms, and Treatment.慢性肾脏病中的胆固醇代谢：生理学、病理机制与治疗。
Adv Exp Med Biol. 2022;1372:119-143. doi: 10.1007/978-981-19-0394-6_9.
9
MiR-200c-3p targets SESN1 and represses the IL-6/AKT loop to prevent cholangiocyte activation and cholestatic liver fibrosis.miR-200c-3p 靶向 SESN1 并抑制 IL-6/AKT 环以防止胆管细胞激活和胆汁淤积性肝纤维化。
Lab Invest. 2022 May;102(5):485-493. doi: 10.1038/s41374-021-00710-6. Epub 2021 Dec 8.
10
The long and the small collide: LncRNAs and small heterodimer partner (SHP) in liver disease.长短碰撞：长链非编码 RNA 和小异二聚体伴侣 (SHP) 在肝脏疾病中的作用。
Mol Cell Endocrinol. 2021 May 15;528:111262. doi: 10.1016/j.mce.2021.111262. Epub 2021 Mar 26.

本文引用的文献

1
DIANA-miRGen v4: indexing promoters and regulators for more than 1500 microRNAs.DIANA-miRGen v4：为超过 1500 种 microRNAs 索引启动子和调控因子。
Nucleic Acids Res. 2021 Jan 8;49(D1):D151-D159. doi: 10.1093/nar/gkaa1060.
2
jouvence, a new human snoRNA involved in the control of cell proliferation.Jouvence，一种参与细胞增殖调控的新型人类小核仁RNA。
BMC Genomics. 2020 Nov 23;21(1):817. doi: 10.1186/s12864-020-07197-3.
3
RNA Drugs and RNA Targets for Small Molecules: Principles, Progress, and Challenges.RNA 药物和小分子的 RNA 靶点：原理、进展与挑战。
Pharmacol Rev. 2020 Oct;72(4):862-898. doi: 10.1124/pr.120.019554.
4
Role of microRNA-7 in liver diseases: a comprehensive review of the mechanisms and therapeutic applications.miR-7 在肝脏疾病中的作用：机制和治疗应用的综合综述。
J Investig Med. 2020 Oct;68(7):1208-1216. doi: 10.1136/jim-2020-001420. Epub 2020 Aug 24.
5
Genetic and Epigenetic Modification of Rat Liver Progenitor Cells via HNF4α Transduction and 5' Azacytidine Treatment: An Integrated miRNA and mRNA Expression Profile Analysis.通过 HNF4α 转导和 5' 氮杂胞苷处理对大鼠肝祖细胞进行遗传和表观遗传修饰：miRNA 和 mRNA 表达谱综合分析。
Genes (Basel). 2020 Apr 29;11(5):486. doi: 10.3390/genes11050486.
6
Proinflammation in maternal and fetal livers and circulating miR-122 dysregulation in a GDM rat model induced by intrauterine programming.宫内编程诱导的 GDM 大鼠模型中母胎肝脏的促炎反应和循环 miR-122 失调。
Mol Cell Endocrinol. 2020 Jun 15;510:110824. doi: 10.1016/j.mce.2020.110824. Epub 2020 Apr 18.
7
Nuclear receptor crosstalk - defining the mechanisms for therapeutic innovation.核受体相互作用——确定治疗创新的机制
Nat Rev Endocrinol. 2020 Jul;16(7):363-377. doi: 10.1038/s41574-020-0349-5. Epub 2020 Apr 17.
8
Obeticholic acid-a new therapy in PBC and NASH.奥贝胆酸——治疗 PBC 和 NASH 的新疗法。
Br Med Bull. 2020 May 15;133(1):95-104. doi: 10.1093/bmb/ldaa006.
9
Emerging drugs for the treatment of primary biliary cholangitis.原发性胆汁性胆管炎的治疗药物新进展。
Expert Opin Emerg Drugs. 2020 Jun;25(2):101-112. doi: 10.1080/14728214.2020.1751814. Epub 2020 May 5.
10
Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells.长链非编码 RNA LINC00844 介导的分子网络调节人肝细胞中药物代谢酶和核受体的表达。
Arch Toxicol. 2020 May;94(5):1637-1653. doi: 10.1007/s00204-020-02706-5. Epub 2020 Mar 28.

非编码 RNA 与核受体在肝脏疾病中的相互作用。

Non-coding RNA crosstalk with nuclear receptors in liver disease.

机构信息

Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States of America; Department of Molecular Medicine, Case Western Reserve University, Cleveland, OH, United States of America.

Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States of America; Department of Gastroenterology and Hepatology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States of America; Department of Molecular Medicine, Case Western Reserve University, Cleveland, OH, United States of America.

出版信息

Biochim Biophys Acta Mol Basis Dis. 2021 May 1;1867(5):166083. doi: 10.1016/j.bbadis.2021.166083. Epub 2021 Jan 24.

DOI:10.1016/j.bbadis.2021.166083
PMID:33497819
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7987766/
Abstract

The dysregulation of nuclear receptors (NRs) underlies the pathogenesis of a variety of liver disorders. Non-coding RNAs (ncRNAs) are defined as RNA molecules transcribed from DNA but not translated into proteins. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two types of ncRNAs that have been extensively studied for regulating gene expression during diverse cellular processes. NRs as therapeutic targets in liver disease have been exemplified by the successful application of their pharmacological ligands in clinics. MiRNA-based reagents or drugs are emerging as flagship products in clinical trials. Advancing our understanding of the crosstalk between NRs and ncRNAs is critical to the development of diagnostic and therapeutic strategies. This review summarizes recent findings on the reciprocal regulation between NRs and ncRNAs (mainly on miRNAs and lncRNAs) and their implication in liver pathophysiology, which might be informative to the translational medicine of targeting NRs and ncRNAs in liver disease.

摘要

核受体 (NRs) 的失调是多种肝脏疾病发病机制的基础。非编码 RNA (ncRNA) 的定义是从 DNA 转录但不翻译成蛋白质的 RNA 分子。microRNAs (miRNAs) 和长非编码 RNA (lncRNAs) 是两种 ncRNA，它们在多种细胞过程中调节基因表达的研究已经很广泛。NRs 作为肝脏疾病的治疗靶点，其药理学配体在临床上的成功应用就是例证。基于 miRNA 的试剂或药物正在临床试验中崭露头角。深入了解 NRs 和 ncRNA 之间的串扰对于开发诊断和治疗策略至关重要。这篇综述总结了 NRs 和 ncRNA（主要是 miRNAs 和 lncRNAs）之间相互调节的最新发现及其在肝脏病理生理学中的意义，这可能对靶向 NRs 和 ncRNA 治疗肝脏疾病的转化医学有帮助。