Clinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, Cattinara University Hospital ASUGI, University of Trieste, Strada di Fiume, 447 - 34149 Trieste, Italy.
Clinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, Cattinara University Hospital ASUGI, University of Trieste, Strada di Fiume, 447 - 34149 Trieste, Italy.
J Neuroimmunol. 2021 Mar 15;352:577488. doi: 10.1016/j.jneuroim.2021.577488. Epub 2021 Jan 20.
Neuromyelitis optica spectrum disorder (NMOSD) is not defined as a classical paraneoplastic neurological syndrome, however there are growing evidences that NMOSD may be rarely associated with cancer. Older (>45 years old) male patients with longitudinally extensive transverse myelitis (LETM) or patients with "area postrema" syndrome (intractable vomiting and hiccups) at onset are at higher risk for neoplasm-associated NMOSD. We report the case of 79-years old man who developed, a month after radiotherapy for prostatic adenocarcinoma, an area postrema syndrome rapidly followed by a LETM involving the whole spinal cord (from C2 to the conus). Aquaporin-4-IgG antibodies were positive in serum.
视神经脊髓炎谱系疾病（NMOSD）不作为一种经典的副肿瘤神经系统综合征，但越来越多的证据表明 NMOSD 可能与癌症罕见相关。起病时为长节段横贯性脊髓炎（LETM）的老年（>45 岁）男性患者或起病时有“后区”综合征（难治性呕吐和呃逆）的患者，发生与肿瘤相关的 NMOSD 的风险更高。我们报告了一例 79 岁男性的病例，他在前列腺腺癌放疗一个月后，迅速出现后区综合征，随后是累及整个脊髓（从 C2 到圆锥）的 LETM。血清中存在水通道蛋白 4-IgG 抗体。
