In Vitro and In Vivo Antibacterial Activity of Gliotoxin Alone and in Combination with Antibiotics against .

Multidrug-resistant bacteria such as methicillin-resistant (MRSA) is one of the major causes of hospital-acquired and community infections and pose a challenge to the human health care system. Therefore, it is important to find new drugs that show activity against these bacteria, both in monotherapy and in combination with other antimicrobial drugs. Gliotoxin (GT) is a mycotoxin produced by and other fungi of the genus. Some evidence suggests that GT shows antimicrobial activity against in vitro, albeit its efficacy against multidrug-resistant strains such asMRSA or vancomycin-intermediate (VISA) strainsis not known. This work aimedto evaluate the antibiotic efficacy of GT as monotherapy or in combination with other therapeutics against MRSA in vitro and in vivo using a infection model.