Faculty of Life Science and Medicine, King's College London, London, UK.
University Hospitals of Derby and Burton, Derby, UK.
Eur J Ophthalmol. 2021 Sep;31(5):2451-2456. doi: 10.1177/1120672120969369. Epub 2021 Jan 26.
To determine the incidence and demographic profile of uveal effusion syndrome (UES), and to describe the visual and anatomic outcome following deep sclerectomy or vortex vein decompression.
The British Ophthalmological Surveillance Unit (BOSU) mails reporting cards monthly to 1149 senior UK ophthalmologists, who are requested to report incident cases of specified rare diseases. UES was included in the reporting system from October 2009 to October 2011. If UES was identified, ophthalmologists were mailed a questionnaire to collect anonymized clinical data at baseline, and 12 months after.
Over 2 years, 29 cases were reported. Two cases were duplicates and 12 failed to meet the eligibility criteria. Of the 15 eligible cases, age ranged from 11 to 91 years (mean 62) and nine were males (60%). Ten patients were hypermetropic; three had an axial length of 19.0 mm or less. Estimated annual incidence was 1.2 per 10 million population. Seven cases were managed nonsurgically, including observation (one case), topical steroids (two cases), systemic steroids (three cases), and cyclodiode laser (one case). Eight cases (11 eyes) underwent full-thickness sclerectomy; the elevated flap was retained in four. The sclera was noted to be thick and rigid during surgery in five cases. Median preoperative visual acuity was 6/18, changing slightly to 6/21.5 at final review, with three eyes showing complete anatomic response, five showing some improvement, and three failing to respond.
UES is extremely rare. It occurs in a range of ages, but is most common in middle-aged, hypermetropic men. Visual acuity can be materially reduced. The most commonly used surgical treatment in the UK is deep sclerectomy.
确定葡萄膜渗漏综合征（UES）的发病率和人口统计学特征，并描述深层巩膜切除术或涡静脉减压术后的视力和解剖结果。
英国眼监测单位（BOSU）每月向 1149 名英国资深眼科医生邮寄报告卡，要求他们报告指定罕见疾病的新发病例。从 2009 年 10 月到 2011 年 10 月，UES 被纳入报告系统。如果确定为 UES，眼科医生会收到一份问卷，以收集基线和 12 个月后的匿名临床数据。
在 2 年期间，报告了 29 例病例。其中两例是重复病例，12 例不符合入选标准。在 15 例符合条件的病例中，年龄范围为 11 至 91 岁（平均 62 岁），9 例为男性（60%）。10 例患者为远视；3 例眼轴长度为 19.0mm 或更短。估计年发病率为每 100 万人中有 1.2 例。7 例病例采用非手术治疗，包括观察（1 例）、局部皮质类固醇（2 例）、全身皮质类固醇（3 例）和激光睫状体光凝（1 例）。8 例（11 只眼）接受了全层巩膜切除术；4 例保留了隆起的瓣。在 5 例病例中，术中发现巩膜增厚且僵硬。术前中位视力为 6/18，最终随访时略有改善至 6/21.5，3 只眼完全解剖反应，5 只眼有所改善，3 只眼无反应。
UES 极为罕见。它发生在一系列年龄段，但最常见于中年、远视的男性。视力可能会显著下降。英国最常用的手术治疗方法是深层巩膜切除术。
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