Kmiecik Matthew J, Tu Frank F, Silton Rebecca L, Dillane Katlyn E, Roth Genevieve E, Harte Steven E, Hellman Kevin M
Department of Ob/Gyn, NorthShore University HealthSystem, Evanston, IL, United States.
Department of Ob/Gyn, Pritzker School of Medicine, University of Chicago, Chicago, IL, United States.
medRxiv. 2021 Jan 18:2020.12.03.20242032. doi: 10.1101/2020.12.03.20242032.
Multisensory hypersensitivity (MSH), which refers to persistent discomfort across sensory modalities, is a risk factor for chronic pain. Developing a better understanding of the neural contributions of disparate sensory systems to MSH may clarify its role in the development of chronic pain. We recruited a cohort of women ( =147) enriched with participants with menstrual pain at risk for developing chronic pain. Visual sensitivity was measured using a periodic pattern-reversal stimulus during EEG. Self-reported visual unpleasantness ratings were also recorded. Bladder pain sensitivity was evaluated with an experimental bladder-filling task associated with early clinical symptoms of chronic pelvic pain. Visual stimulation induced unpleasantness was associated with bladder pain and evoked primary visual cortex excitation; however, the relationship between unpleasantness and cortical excitation was moderated by bladder pain. Thus, future studies aimed at reversing the progression of MSH into chronic pain should prioritize targeting of cortical mechanisms responsible for maladaptive sensory input integration.
多感官超敏反应（MSH）是指跨感觉模态的持续不适，是慢性疼痛的一个风险因素。更好地理解不同感觉系统对MSH的神经贡献，可能会阐明其在慢性疼痛发展中的作用。我们招募了一组女性（n = 147），其中有痛经风险且可能发展为慢性疼痛的参与者较多。在脑电图（EEG）检查期间，使用周期性模式反转刺激来测量视觉敏感性。同时也记录了自我报告的视觉不适感评分。通过一项与慢性盆腔疼痛早期临床症状相关的膀胱充盈实验任务来评估膀胱疼痛敏感性。视觉刺激诱发的不适感与膀胱疼痛相关，并诱发初级视觉皮层兴奋；然而，不适感与皮层兴奋之间的关系受到膀胱疼痛的调节。因此，未来旨在扭转MSH向慢性疼痛发展进程的研究，应优先针对负责适应不良感觉输入整合的皮层机制。
