Khan-Dawood F S, Cai H Y, Dawood M Y
Department of Obstetrics and Gynecology, University of Illinois College of Medicine, Chicago 60612.
Fertil Steril. 1988 Apr;49(4):611-5. doi: 10.1016/s0015-0282(16)59827-6.
Serial paired plasma and salivary progesterone (P) levels were determined in 21 ovulation-induced cycles of 13 women and in 162 luteal saliva samples of 21 normal cycling women. Mean +/- standard error of the mean (SEM) salivary P levels in all ovulation-induced cycles were similar to normal cycles and were 294 +/- 31.5 to 499 +/- 75 pg/ml, whereas the corresponding plasma P levels were 24.9 +/- 5.0 to 51.4 +/- 16.6 ng/ml. Paired plasma and salivary P levels correlated significantly in women induced with clomiphene citrate (r = 0.82), follicle-stimulating hormone (r = 0.80), human menopausal gonadotropins (r = 0.78), and in those who became pregnant (r = 0.95). Luteal phase salivary P levels were 1.0% to 1.3% of the corresponding plasma levels in ovulation-induced cycles. These findings indicate that salivary P may be a useful and convenient alternative to plasma P for assessing ovulation.
在13名女性的21个诱导排卵周期以及21名正常月经周期女性的162份黄体期唾液样本中，测定了配对的血浆和唾液孕酮（P）水平。所有诱导排卵周期中唾液P水平的均值±均值标准误差（SEM）与正常周期相似，为294±31.5至499±75 pg/ml，而相应的血浆P水平为24.9±5.0至51.4±16.6 ng/ml。在接受枸橼酸氯米芬诱导的女性（r = 0.82）、促卵泡生成素诱导的女性（r = 0.80）、人绝经期促性腺激素诱导的女性（r = 0.78）以及怀孕女性（r = 0.95）中，配对的血浆和唾液P水平显著相关。在诱导排卵周期中，黄体期唾液P水平为相应血浆水平的1.0%至1.3%。这些发现表明，唾液P可能是评估排卵的一种有用且便捷的替代血浆P的方法。
