Center of Excellence for Rehabilitation Medicine, UMC Utrecht Brain Center, University Medical Center Utrecht, and De Hoogstraat Rehabilitation, Utrecht, The Netherlands.
Department of Rehabilitation, Physical Therapy Science & Sports, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Muscle Nerve. 2021 May;63(5):678-682. doi: 10.1002/mus.27185. Epub 2021 Feb 9.
In multifocal motor neuropathy (MMN), knowledge about the pattern of treatment response in a wide spectrum of muscle groups, distal as well as proximal, after intravenous immunoglobulin (IVIg) initiation is lacking.
Hand-held dynamometry data of 11 upper and lower limb muscles, from 47 patients with MMN was reviewed. Linear mixed models were used to determine the treatment response after IVIg initiation and its relationship with initial muscle weakness.
All muscle groups showed a positive treatment response after IVIg initiation. Changes in SD scores ranged from +0.1 to +0.95. A strong association between weakness at baseline and the magnitude of the treatment response was found.
Improved muscle strength in response to IVIg appears not only in distal, but to a similar degree also in proximal muscle groups in MMN, with the largest response in muscle groups that show the greatest initial weakness.
在多灶性运动神经病（MMN）中，对于静脉注射免疫球蛋白（IVIg）治疗开始后，广泛的肌肉群（包括远端和近端肌肉）的治疗反应模式，缺乏了解。
回顾了 47 例 MMN 患者的 11 个上肢和下肢肌肉的手持式测力计数据。使用线性混合模型来确定 IVIg 治疗开始后的治疗反应及其与初始肌肉无力的关系。
IVIg 治疗开始后，所有肌肉群均显示出阳性的治疗反应。SD 评分的变化范围为+0.1 至+0.95。在基线时的无力程度与治疗反应的幅度之间存在很强的关联。
对 IVIg 的治疗反应，不仅在远端肌肉中有所改善，而且在 MMN 中也在类似程度上在近端肌肉群中有所改善，在最初无力程度最大的肌肉群中反应最大。
