Liu Yuting, Li Guoxin, Wang Bin
Shanghai Veterinary Research Institute, Chinese Acaclemy of Agricultural Sciences, Shanghai 201100, China.
Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonose, Yangzhou 225009, Jiangsu, China.
Sheng Wu Gong Cheng Xue Bao. 2021 Jan 25;37(1):67-77. doi: 10.13345/j.cjb.200226.
Endoplasmic reticulum (ER) is an important organelle where folding and post-translational modification of secretory and transmembrane proteins take place. During virus infection, cellular or viral unfolded and misfolded proteins accumulate in the ER in an event called ER stress. To maintain the equilibrium homeostasis of the ER, signal-transduction pathways, known as unfolded protein response (UPR), are activated. The viruses in turn manipulate UPR to maintain an environment favorable for virus survival and replication. Herpesviruses are enveloped DNA viruses that produce over 70 viral proteins. Modification and maturation of large quantities of viral glycosylated envelope proteins during virus replication may induce ER stress, while ER stress play both positive and negative roles in virus infection. Here we summarize the research progress of crosstalk between herpesvirus infection and the virus-induced ER stress.
内质网（ER）是一个重要的细胞器，分泌蛋白和跨膜蛋白的折叠及翻译后修饰在此进行。在病毒感染期间，细胞内或病毒来源的未折叠和错误折叠蛋白会在内质网中积累，这一现象称为内质网应激。为维持内质网的平衡稳态，被称为未折叠蛋白反应（UPR）的信号转导通路会被激活。反过来，病毒会操纵UPR以维持有利于病毒生存和复制的环境。疱疹病毒是有包膜的DNA病毒，可产生70多种病毒蛋白。病毒复制过程中大量病毒糖基化包膜蛋白的修饰和成熟可能会诱导内质网应激，而内质网应激在病毒感染中兼具正负两方面作用。在此，我们总结疱疹病毒感染与病毒诱导的内质网应激之间相互作用的研究进展。
