Zeng Zhen, Wang Haining, Zhang Zhifang, Yi Yongzhu
College of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang 212003, Jiangsu, China.
Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Sheng Wu Gong Cheng Xue Bao. 2021 Jan 25;37(1):78-87. doi: 10.13345/j.cjb.200220.
In recent years, the development of new vaccines such as nucleic acid vaccines, genetically engineered vaccines, and synthetic peptide vaccines has achieved rapid development. However, compared with traditional inactivated or live vaccines, these vaccines often have problems such as poor immunogenicity. Therefore, an adjuvant is needed to enhance its effect, and adjuvants have proven to be a key component in vaccines. There are many types of adjuvants, while currently no unified standard for the classification. At present, the most commonly used adjuvants are Aluminum adjuvant and Freund's adjuvant, but new generation vaccines will probably need new generation adjuvants. Thus, this review aims to showcase the current status of immune adjuvants, with the focus on immunomodulatory molecular adjuvant, antigen delivery adjuvant and compound adjuvant. This review provides new insights for the development of novel vaccine adjuvants.
近年来，核酸疫苗、基因工程疫苗和合成肽疫苗等新型疫苗取得了快速发展。然而，与传统的灭活疫苗或活疫苗相比，这些疫苗往往存在免疫原性差等问题。因此，需要佐剂来增强其效果，并且佐剂已被证明是疫苗中的关键成分。佐剂种类繁多，目前尚无统一的分类标准。目前最常用的佐剂是铝佐剂和弗氏佐剂，但新一代疫苗可能需要新一代佐剂。因此，本综述旨在展示免疫佐剂的现状，重点关注免疫调节分子佐剂、抗原递送佐剂和复合佐剂。本综述为新型疫苗佐剂的开发提供了新的见解。
