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Ticagrelor monotherapy following percutaneous coronary intervention for acute coronary syndrome in TWILIGHT patients: still a future for aspirin?

作者信息

Lunardi Mattia, Onuma Yoshinobu, Serruys Patrick W

机构信息

Department of Cardiology, National University of Ireland, University Road, Galway H91 TK33, Ireland.

Division of Cardiology, Department of Medicine, University Hospital of Verona, Verona, Italy.

出版信息

Eur Heart J. 2021 Jul 15;42(27):2708-2709. doi: 10.1093/eurheartj/ehab037.

DOI:10.1093/eurheartj/ehab037
PMID:33501975
Abstract
摘要

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1
Ticagrelor monotherapy following percutaneous coronary intervention for acute coronary syndrome in TWILIGHT patients: still a future for aspirin?
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2
Ticagrelor alone vs. ticagrelor plus aspirin following percutaneous coronary intervention in patients with non-ST-segment elevation acute coronary syndromes: TWILIGHT-ACS.替格瑞洛单药治疗与替格瑞洛联合阿司匹林用于非ST段抬高型急性冠状动脉综合征患者经皮冠状动脉介入治疗后：TWILIGHT-ACS研究
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In ACS treated with drug-eluting stents and 3 mo of DAPT, ticagrelor monotherapy reduced clinical events at 1 y vs. DAPT.在接受药物洗脱支架治疗和 DAPT 治疗 3 个月的 ACS 患者中，与 DAPT 相比，替格瑞洛单药治疗在 1 年时降低了临床事件发生率。
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[Debate on antiplatelet monotherapy: Why not leaving out good old aspirin for clopidogrel or ticagrelor in monotherapy in chronic coronary syndromes after a percutaneous coronary intervention].[抗血小板单药治疗的争论：经皮冠状动脉介入治疗后慢性冠状动脉综合征的单药治疗中，为何不摒弃经典的阿司匹林而选用氯吡格雷或替格瑞洛]
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Pharmacodynamic Comparison of Ticagrelor Monotherapy Versus Ticagrelor and Aspirin in Patients After Percutaneous Coronary Intervention: The TEMPLATE (Ticagrelor Monotherapy and Platelet Reactivity) Randomized Controlled Trial.经皮冠状动脉介入治疗后替格瑞洛单药治疗与替格瑞洛联合阿司匹林治疗患者的药效学比较： TEMPLATE（替格瑞洛单药治疗和血小板反应性）随机对照试验。
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Ticagrelor Monotherapy Versus Ticagrelor With Aspirin in Acute Coronary Syndrome Patients With a High Risk of Ischemic Events.替格瑞洛单药治疗与替格瑞洛联合阿司匹林治疗缺血事件高危急性冠状动脉综合征患者。
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Effect of Ticagrelor Monotherapy vs Ticagrelor With Aspirin on Major Bleeding and Cardiovascular Events in Patients With Acute Coronary Syndrome: The TICO Randomized Clinical Trial.替格瑞洛单药治疗与替格瑞洛联合阿司匹林治疗对急性冠状动脉综合征患者主要出血和心血管事件的影响：TICO 随机临床试验。
JAMA. 2020 Jun 16;323(23):2407-2416. doi: 10.1001/jama.2020.7580.
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Impact of long-term ticagrelor monotherapy following 1-month dual antiplatelet therapy in patients who underwent complex percutaneous coronary intervention: insights from the Global Leaders trial.接受复杂经皮冠状动脉介入治疗的患者在 1 个月双联抗血小板治疗后长期使用替格瑞洛单药治疗的影响：来自全球领导者试验的见解。
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Ticagrelor With or Without Aspirin After PCI: The TWILIGHT Platelet Substudy.经皮冠状动脉介入治疗（PCI）后应用替格瑞洛联合或不联合阿司匹林：TWILIGHT 血小板亚研究。
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Safety and Efficacy of 1-Month Dual Antiplatelet Therapy (Ticagrelor + Aspirin) Followed by 23-Month Ticagrelor Monotherapy in Patients Undergoing Staged Percutaneous Coronary Intervention (A Sub-Study from GLOBAL LEADERS).经皮冠状动脉介入治疗中（来自 GLOBAL LEADERS 的亚研究） 1 个月双联抗血小板治疗（替格瑞洛+阿司匹林）后序贯 23 个月替格瑞洛单药治疗的安全性和有效性。
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