Sinzinger H, O'Grady J, Fitscha P
Department of Nuclear Medicine, University of Vienna, Austria.
J Int Med Res. 1988 Jan-Feb;16(1):39-43. doi: 10.1177/030006058801600104.
Eighteen patients with ischaemic peripheral vascular disease were treated for a 5-week period with either 20 mg aspirin daily, 75 mg dipyridamole three times daily or a combination of these two treatments. Before and after 4 weeks' treatment autologous platelet labelling with 111In was carried out and sites of active vascular platelet uptake monitored, and platelet half-life measured. Neither aspirin nor dipyridamole alone had any effect on platelet uptake or on platelet half-life. The combination of aspirin and dipyridamole resulted in a significant decrease in platelet uptake and a nonsignificant trend towards prolongation of platelet half-life. These findings suggest that this combined therapy may be of benefit in the treatment of atherosclerosis in man.
18例缺血性周围血管疾病患者接受了为期5周的治疗，治疗方式为每日服用20毫克阿司匹林、每日三次服用75毫克双嘧达莫或这两种治疗方法的联合使用。在治疗4周前后，采用铟-111对自体血小板进行标记，监测血管内血小板的活性摄取部位，并测量血小板半衰期。单独使用阿司匹林或双嘧达莫对血小板摄取或血小板半衰期均无任何影响。阿司匹林和双嘧达莫联合使用导致血小板摄取显著减少，血小板半衰期有延长的趋势但不显著。这些发现表明，这种联合疗法可能对人类动脉粥样硬化的治疗有益。
