制备 QSS@AuNPs 和溶剂诱导增强策略用于唾液硫氰酸盐的拉曼测定。
Preparation of QSS@AuNPs and Solvent Inducing Enhancement Strategy for Raman Determination of Salivary Thiocyanate.
机构信息
The Education Ministry Key Lab of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, and Department of Chemistry, Shanghai Normal University, Shanghai 200234, P. R. China.
College of Information, Mechanical and Electrical Engineering, Shanghai Normal University, Shanghai 200234, P. R. China.
出版信息
ACS Appl Mater Interfaces. 2021 Feb 10;13(5):5966-5974. doi: 10.1021/acsami.0c19650. Epub 2021 Jan 27.
Making the substrates form highly dense, homogeneous, and stable hotspots regions is important for the sensitive detection of surface-enhanced Raman spectroscopy (SERS). A new strategy based on solvent-induced (SI) SERS substrate to form a stable interval of the hotspot for detection was explored and the enhancement factor (EF) of our SERS substrates could reach about 1.4 × 10. By preferential adsorption of alcohol solutions by Q-Sepharose microsphere (QSS) in mixed water and alcohol solutions, the size of QSS@AuNPs was dynamically adjusted and the spacing between gold nanoparticles (AuNPs) was adjusted to keep the substrate in the optimal hotspot mode for the sensitive detection of SERS in the liquid state. As a real application case, such a SI-SERS strategy was employed to determine SCN in saliva and a limit of detection (LOD) of about 10 M could be achieved.
使基底形成高密度、均匀且稳定的热点区域对于表面增强拉曼光谱（SERS）的敏感检测非常重要。本研究探索了一种基于溶剂诱导（SI）SERS 基底形成稳定热点区间的新策略，我们的 SERS 基底的增强因子（EF）可达到约 1.4×10。通过 Q-琼脂糖微球（QSS）在混合水和醇溶液中对醇溶液的优先吸附，动态调节 QSS@AuNPs 的尺寸，调整金纳米粒子（AuNPs）之间的间距，使基底保持在液态 SERS 敏感检测的最佳热点模式。作为一个实际应用案例，这种 SI-SERS 策略被用于检测唾液中的 SCN，检测限（LOD）约为 10M。
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