Bratisl Lek Listy. 2021;122(2):89-94. doi: 10.4149/BLL_2021_013.
Studies assessing the unicentric and prospective comparison of efficacy of cryoballoon pulmonary vein isolation in idiopathic and non-idiopathic atrial fibrillation (AF) patients are missing. The aim of this study was to compare a single procedural outcome in these subgroups of AF patients.
A total of 208 patients with drug resistant AF were included in this study. Among them, 36 patients had idiopathic AF and 172 patients had non-idiopathic AF. The efficacy endpoint was freedom from any atrial arrhythmia lasting >30 s after a 3-months blanking period.
The freedom from atrial arrhythmias without antiarrhythmic drugs after 1 and 3 years of follow-up, respectively, was 85.2 % and 70.4 % in patients with idiopathic AF; and 64.6 % and 39.9 % in patients with non-idiopathic AF (p=0.021). Moreover, the success rate when analysing only paroxysmal AF patients after 1 and 3 years of follow-up, respectively, was 95.7 % and 82 % in patients with idiopathic AF; and 72.6 % and 47 % in patients with non-idiopathic AF (p=0.022).
A single cryoballoon pulmonary vein isolation was more effective in preventing atrial arrhythmias relapses in idiopathic AF patients compared to non-idiopathic AF patients. The best efficacy outcomes were observed in patients with paroxysmal idiopathic AF (Tab. 5, Fig. 2, Ref. 25).
缺乏评估冷冻球囊肺静脉隔离在特发性和非特发性心房颤动（AF）患者中单中心前瞻性疗效比较的研究。本研究旨在比较这些 AF 患者亚组的单一手术结果。
共纳入 208 例药物难治性 AF 患者。其中，36 例为特发性 AF，172 例为非特发性 AF。疗效终点是在 3 个月空白期后无任何持续 >30 s 的房性心律失常。
分别在 1 年和 3 年随访时，特发性 AF 患者无抗心律失常药物的房性心律失常发生率分别为 85.2%和 70.4%；而非特发性 AF 患者分别为 64.6%和 39.9%（p=0.021）。此外，仅在 1 年和 3 年随访时分析阵发性 AF 患者，特发性 AF 患者的成功率分别为 95.7%和 82%；而非特发性 AF 患者分别为 72.6%和 47%（p=0.022）。
与非特发性 AF 患者相比，单次冷冻球囊肺静脉隔离术在预防特发性 AF 患者心房心律失常复发方面更有效。在阵发性特发性 AF 患者中观察到最佳疗效（表 5，图 2，参考文献 25）。
