Reck G, Klein A, Breckwoldt M
Universitäts-Frauenklinik Homburg/Saar.
Geburtshilfe Frauenheilkd. 1988 Jan;48(1):32-4. doi: 10.1055/s-2008-1035691.
The present study compares the negative feed back action of cortisol and cortison on oestriol production in late human pregnancy. 10 women from the 38th to 40th week of gestation volunteered in this study. All had uncomplicated courses of pregnancy and delivered healthy babies at term. 5 patients received a continuous infusion of 100 mg Cortisol from 10 a.m. to 12 a.m. To the other 5 patients 100 mg Cortison were infused during the same period. Blood specimens (5 ml) were drawn in 60 and 30 minutes intervals from 8 a.m. to 5 p.m. Plasma levels of unconjugated oestriol were measured by radioimmunoassay. The suppression of oestriol levels was nearly identical in both groups: After Cortisol oestriol concentrations decreased from 17.1 +/- 9.1 ng/ml to 6.0 +/- 1.2 ng/ml (p less than 0.001) and after Cortison from 15.5 +/- 5.8 ng/ml to 5.9 +/- 1.8 ng/ml (p less than 0.001), respectively. According to these results the placental metabolism of maternal cortisol to cortison does not impair the negative feed back action of this hormone on the foetal hypothalamus-hypophysis-system.
本研究比较了皮质醇和可的松对人类妊娠晚期雌三醇产生的负反馈作用。10名妊娠38至40周的女性自愿参与本研究。所有患者孕期过程均无并发症，足月分娩出健康婴儿。5名患者从上午10点至中午12点接受100毫克皮质醇的持续输注。另外5名患者在同一时期输注100毫克可的松。从上午8点至下午5点，每隔60分钟和30分钟采集一次血样（5毫升）。采用放射免疫分析法测定血浆中游离雌三醇的水平。两组中雌三醇水平的抑制情况几乎相同：皮质醇输注后，雌三醇浓度从17.1±9.1纳克/毫升降至6.0±1.2纳克/毫升（p<0.001），可的松输注后，雌三醇浓度从15.5±5.8纳克/毫升降至5.9±1.8纳克/毫升（p<0.001）。根据这些结果，母体皮质醇向可的松的胎盘代谢不会损害该激素对胎儿下丘脑 - 垂体系统的负反馈作用。
