琥珀酰嘌呤对豚鼠子宫的收缩作用。

Contractile effect of succinylpurines on guinea pig uterus.

Nishida Y, Miyamoto T

Department of Medicine and Physical Therapy, University of Tokyo School of Medicine, Japan.

Gen Pharmacol. 1988;19(2):277-9. doi: 10.1016/0306-3623(88)90076-6.

Abstract

The effects of adenosine analogues on isolated guinea pig uterus were studied in vitro. 2. Low concentrations of adenosine analogues contracted guinea pig uterus. The relative potencies of contractive effect were adenosine greater than AMP greater than ADP greater than ATP greater than 2-chloroadenosine greater than N6-phenylisopropyl-adenosine (PIA) greater than 5'-N-ethylcarboxamidoadenosine (NECA) greater than adenylosuccinate greater than succinyladenosine. 3. Pretreatment of the uterus strips with theophylline blocked the action of adenosine. However, dipyridamole did not impair the adenosine actions. 4. The role of naturally occurring adenosine analogues was discussed.

摘要

体外研究了腺苷类似物对离体豚鼠子宫的作用。2. 低浓度的腺苷类似物使豚鼠子宫收缩。收缩作用的相对效力为：腺苷＞AMP＞ADP＞ATP＞2-氯腺苷＞N6-苯异丙基腺苷（PIA）＞5'-N-乙基羧酰胺腺苷（NECA）＞腺苷酸琥珀酸＞琥珀酰腺苷。3. 用茶碱预处理子宫条可阻断腺苷的作用。然而，双嘧达莫并不损害腺苷的作用。4. 讨论了天然存在的腺苷类似物的作用。