Yang Yao, Zhang Wei, Liu Yang, Li Gang, Zhang Han, Fan Xing, Su Junwu, Liu Yinglong, Fan Xiangming
Pediatric Cardiac Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
J Card Surg. 2021 Mar;36(3):1012-1017. doi: 10.1111/jocs.15373. Epub 2021 Jan 27.
Ebstein's anomaly (EA) is a kind of congenital heart disease, which is currently widely treated by cone reconstruction. However, the prediction of postoperative recovery is still challenging.
A retrospective analysis was performed on EA cases undergoing cone reconstruction from January 2010 to January 2016. Univariate and multivariate logistic regression analyses were performed, with postoperative adverse events defined as dependent variable and pre- and intraoperative parameters defined as independent variables. The predictive capacity of preoperative percutaneous oxygen saturation (SPO ) and Great Ormond Street (GOS) score was evaluated using areas under the curve of the receiver operating characteristic (ROC).
Preoperative SPO was 95.7 ± 5.20%. Cardiopulmonary bypass, aortic cross-clamp, postoperative mechanical ventilation, and hospitalization time were 101.7 ± 28.26 min, 60.9 ± 18.04 min, 16 h (8, 22), and 8 days (7, 11), respectively. The incidence of total postoperative adverse events, including low cardiac output syndrome, mechanical ventilation more than 3 days, postoperative hospitalization more than 2 weeks, postoperative reintubation, extracorporeal membrane oxygenation assistance, and death, was 13.1% (n = 13). Low preoperative SPO (p = .001, odds ratio [OR] = 0.834), GOS score (p = .021, OR = 0.368), and cardiopulmonary bypass time (p = .034, OR = 1.021) were risk factors for adverse events. Multivariate logistic regression analysis showed that low preoperative SPO (p = .002, OR = 0.846) and GOS score (p = .043, OR = 0.577) were independent risk factors for adverse events. The areas of SPO and GOS score under the ROC curve were 0.764 and 0.740, respectively.
Low preoperative SPO and GOS score were predictors of adverse events after cone reconstruction, and SPO was more convenient and objective than the GOS score.
埃布斯坦畸形(EA)是一种先天性心脏病,目前广泛采用圆锥重建术进行治疗。然而,术后恢复情况的预测仍然具有挑战性。
对2010年1月至2016年1月接受圆锥重建术的EA病例进行回顾性分析。进行单因素和多因素逻辑回归分析,将术后不良事件定义为因变量,术前和术中参数定义为自变量。使用受试者操作特征(ROC)曲线下面积评估术前经皮血氧饱和度(SPO)和大奥蒙德街(GOS)评分的预测能力。
术前SPO为95.7±5.20%。体外循环、主动脉阻断、术后机械通气和住院时间分别为101.7±28.26分钟、60.9±18.04分钟、16小时(8,22)和8天(7,11)。术后不良事件总发生率为13.1%(n = 13),包括低心排血量综合征、机械通气超过3天、术后住院超过2周、术后再次插管、体外膜肺氧合辅助和死亡。术前SPO低(p = 0.001,比值比[OR]=0.834)、GOS评分(p = 0.021,OR = 0.368)和体外循环时间(p = 0.034,OR = 1.021)是不良事件的危险因素。多因素逻辑回归分析显示,术前SPO低(p = 0.002,OR = 0.846)和GOS评分(p = 0.043,OR = 0.577)是不良事件的独立危险因素。ROC曲线下SPO和GOS评分的面积分别为0.764和0.740。
术前SPO低和GOS评分是圆锥重建术后不良事件的预测指标,且SPO比GOS评分更方便、客观。