Clinical correlates of hypotension in patients with acute organophosphorus poisoning.

BACKGROUND

The aim of the present study is to describe the clinical correlates of hypotension and its associated outcomes in patients with acute organophosphorus poisoning (AOPP).

METHODS

In this retrospective cohort study, we analyzed data pertaining to 871 patients with AOPP who were treated at two hospitals. Data from hypotensive and non-hypotensive patients were compared to identify clinical correlates of hypotension. We also evaluated the association between clinical parameters (including hypotension) and in-hospital mortality.

RESULTS

The incidence of hypotension in AOPP patients was 16.4%. Hypotensive patients showed significantly higher in-hospital mortality (1.1% vs. 39.9%, <0.001). Advanced age (odds ratio [] 1.25, 95% confidence interval [] 1.08-1.44), history of diabetes ( 2.65, 95% 1.14-5.96), and increased white blood cell count ( 1.06, 95% 1.03-1.09), plasma cholinesterase ( 0.91, 95% C 0.84-0.94), plasma albumin ( 0.88, 95% 0.85-0.92), serum amylase ( 1.01, 95% 1.01-1.02), and blood pH ( 0.64, 95% 0.54-0.75) were significantly associated with hypotension. After adjusting for potential confounders, hypotension was associated with increased in-hospital mortality (hazard ratio 8.77-37.06, depending on the controlled variables).

CONCLUSIONS

Hypotension is a common complication of AOPP and is associated with increased in-hospital mortality. Advanced age, history of diabetes, and changes in laboratory parameters were associated with hypotension in AOPP patients.