Dong Ning, Lu Zhe-Xi, Li Xing-Liang, Li Wei, Pang Li, Xing Ji-Hong
Department of Emergency, the First Hospital of Jilin University, Changchun 130021, China.
School of Medicine, Pennsylvania State College of Medicine, Hershey 17033, USA.
World J Emerg Med. 2021;12(1):24-28. doi: 10.5847/wjem.j.1920-8642.2021.01.004.
The aim of the present study is to describe the clinical correlates of hypotension and its associated outcomes in patients with acute organophosphorus poisoning (AOPP).
In this retrospective cohort study, we analyzed data pertaining to 871 patients with AOPP who were treated at two hospitals. Data from hypotensive and non-hypotensive patients were compared to identify clinical correlates of hypotension. We also evaluated the association between clinical parameters (including hypotension) and in-hospital mortality.
The incidence of hypotension in AOPP patients was 16.4%. Hypotensive patients showed significantly higher in-hospital mortality (1.1% vs. 39.9%, <0.001). Advanced age (odds ratio [] 1.25, 95% confidence interval [] 1.08-1.44), history of diabetes ( 2.65, 95% 1.14-5.96), and increased white blood cell count ( 1.06, 95% 1.03-1.09), plasma cholinesterase ( 0.91, 95% C 0.84-0.94), plasma albumin ( 0.88, 95% 0.85-0.92), serum amylase ( 1.01, 95% 1.01-1.02), and blood pH ( 0.64, 95% 0.54-0.75) were significantly associated with hypotension. After adjusting for potential confounders, hypotension was associated with increased in-hospital mortality (hazard ratio 8.77-37.06, depending on the controlled variables).
Hypotension is a common complication of AOPP and is associated with increased in-hospital mortality. Advanced age, history of diabetes, and changes in laboratory parameters were associated with hypotension in AOPP patients.
本研究旨在描述急性有机磷中毒（AOPP）患者低血压的临床相关因素及其相关结局。
在这项回顾性队列研究中，我们分析了两家医院收治的871例AOPP患者的数据。比较了低血压患者和非低血压患者的数据，以确定低血压的临床相关因素。我们还评估了临床参数（包括低血压）与院内死亡率之间的关联。
AOPP患者低血压的发生率为16.4%。低血压患者的院内死亡率显著更高（1.1%对39.9%，<0.001）。高龄（比值比[OR]1.25，95%置信区间[CI]1.08 - 1.44）、糖尿病史（OR 2.65，95%CI 1.14 - 5.96）、白细胞计数升高（OR 1.06，95%CI 1.03 - 1.09）、血浆胆碱酯酶（OR 0.91，95%CI 0.84 - 0.94）、血浆白蛋白（OR 0.88，95%CI 0.85 - 0.92）、血清淀粉酶（OR 1.01，95%CI 1.01 - 1.02）和血液pH值（OR 0.64，95%CI 0.54 - 0.75）与低血压显著相关。在调整潜在混杂因素后，低血压与院内死亡率增加相关（风险比为8.77 - 37.06，取决于控制变量）。
低血压是AOPP的常见并发症，与院内死亡率增加相关。高龄、糖尿病史和实验室参数变化与AOPP患者的低血压相关。
