Peck Jacquelin, Nguyen Anh Thy H, Dey Aditi, Amankwah Ernest K, Rehman Mohamed, Wilsey Michael
Department of Anesthesiology, Mount Sinai Medical Center, Miami Beach, FL, USA.
Institute for Clinical and Translational Research, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA.
Pediatr Gastroenterol Hepatol Nutr. 2021 Jan;24(1):100-108. doi: 10.5223/pghn.2021.24.1.100. Epub 2021 Jan 8.
Percutaneous endoscopic gastrostomy (PEG) tube placements are commonly performed pediatric endoscopic procedures. Because of underlying disease, these patients are at increased risk for airway-related complications. This study compares patient characteristics and complications following initial PEG insertion with general endotracheal anesthesia (GETA) vs. anesthesia-directed deep sedation with a natural airway (ADDS).
All patients 6 months to 18 years undergoing initial PEG insertion within the endoscopy suite were considered for inclusion in this retrospective cohort study. Selection of GETA vs. ADDS was made by the anesthesia attending after discussion with the gastroenterologist.
This study included 168 patients (GETA n=38, ADDS n=130). Cohorts had similar characteristics with respect to sex, race, and weight. Compared to ADDS, GETA patients were younger (1.5 years vs. 2.9 years, =0.04), had higher rates of severe American Society of Anesthesiologists (ASA) disease severity scores (ASA 4-5) (21% vs. 3%, <0.001), and higher rates of cardiac comorbidities (39.5% vs. 18.5%, =0.02). Significant associations were not observed between GETA/ADDS status and airway support, 30-day readmission, fever, or pain medication in unadjusted or adjusted models. GETA patients had significantly increased length of stay (e=1.55, 95% confidence interval [CI]=1.11-2.18) after adjusting for ASA class, room time, anesthesia time, fever, and cardiac diagnosis. GETA patients also had increased room time (e=1.20, 95% CI=1.08-1.33) and anesthesia time (e=1.50, 95% CI=1.30-1.74) in adjusted models.
Study results indicate that younger and higher risk patients are more likely to undergo GETA. Children selected for GETA experienced longer room times, anesthesia times, and hospital length of stay.
经皮内镜下胃造口术(PEG)置管是常见的儿科内镜操作。由于潜在疾病,这些患者发生气道相关并发症的风险增加。本研究比较了初次PEG置管时采用全身气管内麻醉(GETA)与自然气道麻醉导向深度镇静(ADDS)后的患者特征及并发症。
所有在内镜检查室接受初次PEG置管的6个月至18岁患者均纳入本回顾性队列研究。GETA与ADDS的选择由麻醉主治医师在与胃肠病学家讨论后做出。
本研究纳入168例患者(GETA组n = 38,ADDS组n = 130)。两组在性别、种族和体重方面具有相似特征。与ADDS组相比,GETA组患者更年轻(1.5岁对2.9岁,P = 0.04),美国麻醉医师协会(ASA)疾病严重程度评分较高(ASA 4 - 得分)(21%对3%,P < 0.001),以及心脏合并症发生率较高(39.5%对18.5%,P = 0.02)。在未调整或调整模型中,未观察到GETA/ADDS状态与气道支持、30天再入院、发热或止痛药物之间存在显著关联。在调整了ASA分级、检查室时间、麻醉时间、发热和心脏诊断后,GETA组患者的住院时间显著延长(P = 1.55,95%置信区间[CI] = 1.11 - 2.18)。在调整模型中,GETA组患者的检查室时间(P = 1.20,95% CI = 1.08 - 1.33)和麻醉时间(P = 1.50,95% CI = 1.30 - 1.74)也有所增加。
研究结果表明,年龄较小和风险较高的患者更有可能接受GETA。选择GETA的儿童检查室时间、麻醉时间和住院时间更长。