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采用紧凑型纳束离子径迹探测器首次测量离子簇的大小分布。

First measurements of ionization cluster-size distributions with a compact nanodosimeter.

机构信息

Radiotherapy Hirslanden, Zurich, Switzerland.

Department of Physics, University of Zurich, Zurich, Switzerland.

出版信息

Med Phys. 2021 May;48(5):2566-2571. doi: 10.1002/mp.14738. Epub 2021 Mar 24.

Abstract

PURPOSE

A nanodosimeter is a type of detector which measures single ionizations in a small gaseous volume in order to obtain ionization cluster size probability distributions for characterization of radiation types. Working nanodosimeter detectors are usually bulky machines which require a lot of space. In this work, the authors present a compact ceramic nanodosimeter detector and report on first measurements of cluster size distributions of 5 MeV alpha particles.

METHODS

Single ionization measurements are achieved by applying a weak electric field to collect positive ions in a hole in a ceramic plate. Inside the ceramic plate, due to a strong electric field, the ions are accelerated and produce impact-ionizations. The resulting electron avalanche is detected in a read-out electrode. A Bayesian unfolding algorithm is then applied to the experimentally obtained cluster size distributions to reconstruct the true cluster size distributions.

RESULTS

Experimentally obtained cluster size distributions by the compact nanodosimeter detector are presented. The reconstructed cluster size distributions agreed well with Monte Carlo simulated cluster size distributions for small volumes (diameter = 2.5 nm). For larger volumes, discrepancies between the reconstructed cluster size distributions and cluster size distributions from Monte Carlo simulations were observed.

CONCLUSIONS

For the first time, ionization cluster size probability distributions could be obtained by a small and compact nanodosimeter detector. This signifies the achievement of a critical step toward the wide application of nanodosimetric characterization of radiation types including in clinical environments.

摘要

目的

纳米剂量计是一种探测器,用于测量小体积气体中的单次电离,以获得用于辐射类型特征描述的电离簇大小概率分布。工作中的纳米剂量计探测器通常是庞大的机器,需要大量的空间。在这项工作中,作者提出了一种紧凑型陶瓷纳米剂量计探测器,并报告了对 5 MeV 阿尔法粒子簇大小分布的首次测量结果。

方法

通过在陶瓷板上的孔中施加弱电场来收集正离子,从而实现单次电离测量。在陶瓷板内部,由于强电场的作用,离子被加速并产生碰撞电离。在读出电极中检测到由此产生的电子雪崩。然后,应用贝叶斯展开算法对实验获得的簇大小分布进行反演,以重建真实的簇大小分布。

结果

呈现了由紧凑型纳米剂量计探测器获得的实验簇大小分布。对于小体积(直径=2.5nm),重建的簇大小分布与蒙特卡罗模拟的簇大小分布吻合良好。对于较大的体积,观察到重建的簇大小分布与蒙特卡罗模拟的簇大小分布之间存在差异。

结论

首次通过小型紧凑型纳米剂量计探测器获得了电离簇大小概率分布。这标志着朝着包括临床环境在内的辐射类型的纳米剂量学特征描述的广泛应用迈出了关键的一步。

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