Structural Interventional Cardiology, Careggi University Hospital, Florence, Italy.
Future Cardiol. 2021 Sep;17(6):945-951. doi: 10.2217/fca-2020-0042. Epub 2021 Jan 28.
A longtime aspiration of interventional cardiologists remains to improve the long-term impact of stent permanence in coronaries to restore original vessel patency and physiological endothelium response. Bioresorbable vascular scaffolds were considered revolutionary in coronary devices, but several trials were disappointing; thus, the challenge in this field remains. DESolve is a novolimus-eluting poly-L-lactide-based polymer scaffold that dissolves through a bio-reabsorption mechanism, vanishing completely in 2 years. Its ability to supply the necessary radial strength to support the vessel for the critical early months after delivery is an important feature showing a unique self-correction property, which reduces incomplete stent apposition. Overexpansion has a good, safe margin with DESolve. This review aims to provide an overview of this controversial topic.
介入心脏病学家的长期愿望仍然是改善支架在冠状动脉中的长期存在对恢复原始血管通畅性和生理内皮反应的影响。生物可吸收血管支架被认为是冠状动脉器械的革命性进展，但几项试验令人失望；因此，该领域仍然存在挑战。DESolve 是一种基于聚左旋乳酸的新型洗脱药物洗脱多聚物支架，通过生物吸收机制溶解，在 2 年内完全消失。它能够提供必要的径向强度，以在交付后的关键早期几个月内支撑血管，这是一个重要的特点，显示出独特的自我修正特性，减少了不完全支架贴壁。DESolve 具有良好的、安全的过度扩张余地。本综述旨在提供该有争议话题的概述。
