Division of Developmental Medicine, Massachusetts and Harvard Medical School, Boston Children's Hospital, Fegan 10, 300 Longwood Avenue, Boston, MA, 02115, USA.
Department of Pediatrics, Baylor College of Medicine and Meyer Center for Developmental Pediatrics, Texas Children's Hospital, Houston, TX, USA.
J Autism Dev Disord. 2021 Dec;51(12):4471-4485. doi: 10.1007/s10803-021-04879-z. Epub 2021 Jan 28.
The objective of this study was to identify subgroups of toddlers with DSM-5 ASD based on core ASD symptoms using a person-based analytical framework. This is a retrospective study of 500 toddlers (mean age 26 months, 79% male) with DSM-5 ASD. Data were analyzed using latent class analyses in which profiles were formed based on ASD symptomatology. Social communication (SC) symptoms favored a three-class solution, while restricted/repetitive behaviors (RRBs) favored a two-class solution. Classes with higher consistency of SC deficits were younger, with lower developmental functioning. The class with more RRBs was older, with higher functioning. If confirmed in other populations, these classes may more precisely characterize subgroups within the heterogeneous group of toddlers at time of ASD diagnosis.
本研究旨在基于 DSM-5 自闭症谱系障碍（ASD）的核心症状，采用基于个体的分析框架，确定幼儿亚群。这是一项对 500 名幼儿（平均年龄 26 个月，79%为男性）的回顾性研究，他们均患有 DSM-5 ASD。使用潜在类别分析对数据进行了分析，根据 ASD 症状形成了特征。社交沟通（SC）症状倾向于三分类解决方案，而受限/重复行为（RRBs）则倾向于二分类解决方案。具有更高一致性的 SC 缺陷的类别更年轻，发育功能更低。具有更多 RRBs 的类别年龄更大，功能更高。如果在其他人群中得到证实，这些类别可能会更精确地描述 ASD 诊断时异质幼儿群体中的亚组。
