翻译后修饰在MCL1调控中的作用

The role of post-translational modifications in the regulation of MCL1.

机构信息

School of Bioengineering & Province Key Laboratory of Protein Modification and Disease, Liaoning Province, Dalian University of Technology, China.

出版信息

Cell Signal. 2021 May;81:109933. doi: 10.1016/j.cellsig.2021.109933. Epub 2021 Jan 27.

DOI:10.1016/j.cellsig.2021.109933

PMID:33508399

Abstract

Apoptosis is an evolutionarily conserved form of programed cell death (PCD) that has a vital effect on early embryonic development, tissue homeostasis and clearance of damaged cells. Dysregulation of apoptosis can lead to many diseases, such as Alzheimer's disease, cancer, AIDS and heart disease. The anti-apoptotic protein MCL1, a member of the BCL2 family, plays important roles in these physiological and pathological processes. Its high expression is closely related to drug resistances in the treatment of tumor. This review summarizes the structure and function of MCL1, the types of post-translational modifications of MCL1 and their effects on the functions of MCL1, as well as the treatment strategies targeting MCL1 in cancer therapy. The research on the fine regulation of MCL1 will be favorable to the provision of a promising future for the design and screening of MCL1 inhibitors.

摘要

细胞凋亡是一种进化上保守的程序性细胞死亡（PCD）形式，对早期胚胎发育、组织稳态和受损细胞的清除具有至关重要的作用。细胞凋亡失调可导致许多疾病，如阿尔茨海默病、癌症、艾滋病和心脏病。抗凋亡蛋白MCL1是BCL2家族的成员之一，在这些生理和病理过程中发挥着重要作用。其高表达与肿瘤治疗中的耐药性密切相关。本文综述了MCL1的结构与功能、MCL1的翻译后修饰类型及其对MCL1功能的影响，以及癌症治疗中靶向MCL1的治疗策略。对MCL1精细调控的研究将有助于为MCL1抑制剂的设计和筛选提供广阔的前景。