氯贝丁酯给药后大鼠肝脏和肾脏中嘧啶核苷酸的生物合成及细胞色素P-450水平（一项体内研究）
Biosynthesis of pyrimidine nucleotides and level of cytochrome P-450 in rat liver and kidney after clofibrate administration (an in vivo study).
作者信息
Seifert J, Machková Z
机构信息
Institute of Pharmacology, Czechoslovak Academy of Sciences, Prague.
出版信息
J Cancer Res Clin Oncol. 1988;114(1):59-63. doi: 10.1007/BF00390486.
Like other lipid-soluble xenobiotics, clofibrate (ethyl-2-(4-chlorophenoxy)-2-methylpropanoate) increased the level of microsomal cytochrome P-450 in liver and decreased the utilization of 14C-orotic acid for the synthesis of hepatic cytidine nucleotides. This phenomenon was associated with the increased (a) uptake of 14C-cytidine, (b) total content of cytidine components of the acid-soluble extract and (c) utilization of this nucleoside for the synthesis of RNA. No changes were observed in uridine components. Clofibrate also increased the level of cytochrome P-450 in kidney microsomes; the degree of induction was almost the same as in the liver. The variations of renal pyrimidine metabolism after administration of the drug were analogous to those observed in the liver.
与其他脂溶性外源性物质一样，氯贝丁酯（2-(4-氯苯氧基)-2-甲基丙酸乙酯）可提高肝脏微粒体细胞色素P-450的水平，并降低14C-乳清酸用于合成肝胞苷核苷酸的利用率。这种现象与以下情况相关：(a) 14C-胞苷摄取增加；(b) 酸溶性提取物中胞苷成分的总含量增加；(c) 该核苷用于合成RNA的利用率增加。尿苷成分未观察到变化。氯贝丁酯还可提高肾微粒体细胞色素P-450的水平；诱导程度与肝脏几乎相同。给药后肾脏嘧啶代谢的变化与在肝脏中观察到的变化相似。
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