Department of Orthopaedics and Traumatology, City Hospital, Kayseri, Turkey.
Department of Orthopaedics and Traumatology, Erciyes University Medical Faculty, Kayseri, Turkey.
Ann Vasc Surg. 2021 Jul;74:301-305. doi: 10.1016/j.avsg.2020.12.018. Epub 2021 Jan 27.
The study aimed to assess the effects of serum YKL-40 level on patency at the repair site in patients who underwent arterial repair at the level of the forearm.
The study included 58 subjects, including 29 patients (aged 18-50 years) who had ulnar or radial artery injury secondary to cut injury to wrist between June 2015 and November 2019 and no comorbid disease and 29 age- and sex-matched healthy controls. The vascular patency was assessed using Doppler sonography in patients who underwent arterial repair at the level of the forearm. The patients were defined as flow failure if the blood flow was ≤50%, and sufficient flow if the blood flow was >50% of those in the synonymous artery on the intact extremity. The YKL-40 level differences in the patient and control groups were compared to those in the sufficient and insufficient flow groups.
The patients were stratified into 2 groups based on the presence of sufficient flow. The mean YKL level was 11.96 ± 8.87 in the sufficient flow groups, whereas it was 32.22 ± 15.43 in the insufficient flow groups (p= 0.038). Besides, it was found that each unit of increase in the YKL-40 level increased the likelihood of having flow failure by 1.128.
Based on our results, it was observed that over-expression of the YKL-40 level has adverse effects on patency following arterial repair.
本研究旨在评估血清 YKL-40 水平对前臂动脉修复患者修复部位通畅率的影响。
本研究纳入了 58 名受试者，包括 29 名（年龄 18-50 岁）因腕部切割伤导致尺动脉或桡动脉损伤且无合并症的患者和 29 名年龄和性别匹配的健康对照者。采用多普勒超声评估前臂动脉修复患者的血管通畅性。如果血流≤50%，则将患者定义为血流失败，如果血流>未损伤肢体相同动脉的 50%，则定义为血流充足。比较患者和对照组以及血流充足和不足组的 YKL-40 水平差异。
根据血流是否充足，将患者分为 2 组。血流充足组的平均 YKL 水平为 11.96±8.87，而血流不足组的平均 YKL 水平为 32.22±15.43（p=0.038）。此外，YKL-40 水平每增加 1 个单位，血流失败的可能性就会增加 1.128。
根据我们的研究结果，YKL-40 水平的过度表达对动脉修复后的通畅率有不良影响。
