Carter J R, Leeson M C, Thompson G H, Kalamchi A, Kelly C M, Makley J T
Department of Pathology, Case Western Reserve University, Cleveland, Ohio.
J Pediatr Orthop. 1988 Mar-Apr;8(2):187-95.
Histopathologic and histochemical studies were performed on the entire physes and contiguous structures of five knees (three patients) with late-onset tibia vara (Blount's disease). A constellation of abnormalities of both medial and lateral physeal components resulted in disorganization and misalignment of the physeal zones. The changes were remarkably similar to those observed in both infantile tibia vara and slipped capital femoral epiphysis, suggesting a common etiology. Our evaluation indicates that asymmetric compressive and shear forces acting across the proximal tibial physis effect its disruption and causes suppression and deviation of normal endochondral ossification, thereby resulting in tibia vara.
对5个膝关节（3例患者）的整个生长板及相邻结构进行了组织病理学和组织化学研究，这些膝关节患有晚发性胫骨内翻（布朗特病）。内侧和外侧生长板成分的一系列异常导致生长板区域紊乱和排列不齐。这些变化与婴儿型胫骨内翻和股骨头骨骺滑脱中观察到的变化非常相似，提示存在共同的病因。我们的评估表明，作用于胫骨近端生长板的不对称压缩力和剪切力会导致其破坏，并引起正常软骨内成骨的抑制和偏移，从而导致胫骨内翻。
