• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

石榴提取物中生物活性化合物对衰老的治疗潜力以及FOXO直系同源物DAF-16在……中的协同作用

Therapeutic potential of bioactive compounds from Punica granatum extracts against aging and complicity of FOXO orthologue DAF-16 in .

作者信息

Chaubey Mukesh G, Chauhan Anita P, Chokshi Pooja R, Amin Rahi S, Patel Stuti N, Madamwar Datta, Rastogi Rajesh P, Singh Niraj Kumar

机构信息

Department of Biotechnology, Shri Alpesh N. Patel P.G. Institute of Science and Research, Anand-388001, Gujarat, India.

Post-Graduate Department of Biosciences, UGC-Centre of Advanced Study, Sardar Patel University, Vadtal Road, Satellite Campus, Bakrol, Anand, Gujarat 388 315, India.

出版信息

EXCLI J. 2021 Jan 11;20:80-98. doi: 10.17179/excli2020-3011. eCollection 2021.

DOI:10.17179/excli2020-3011
PMID:33510593
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7838930/
Abstract

Some natural fruits have significant importance in improving health which provides many nutritional supplements essential to maintain proper metabolism with the age. In this study, phytochemical screening of extract (methanolic) of arils, outer and inner peels was confirmed by the respective spot tests. Quantification of phytochemical constituents revealed the plentiful of total phenols in the outer peels in comparison to inner peels and juice whereas total flavonoids and vitamin C are abundant in inner peel and juice, respectively. High-performance liquid chromatography, Gas chromatography along with mass spectrometry and Fourier-transform infrared spectroscopy analysis revealed the presence of compound 9, 17-octadecadienal, (Z) in the outer/inner peels. A compound N-hexadecanoic acid was also observed in the outer peels. Extracts from every section of the fruits were comprehensively evaluated for their antioxidant activity. Contrary to fruit aril juice, the extracts of outer and inner peels exhibited significant and dose-dependent antioxidant and radical-scavenging potentials. The supplementation of extracts (PGEs) significantly enhanced the lifespan of . The protective effect of PGEs was also observed against oxidative stress in . Additionally, the involvement of FOXO orthologue DAF-16 dependent longevity was obtained with PGEs (outer peel and inner peel) fed TJ356 worms. Overall, the results indicate the vital role of PGEs especially the extracts of outer peels in life-saving mechanisms of by virtue of their antioxidant asset and life-prolonging effects via dependent Insulin signaling pathway. See also Figure 1(Fig. 1).

摘要

一些天然水果对改善健康具有重要意义，它们提供了许多维持随着年龄增长的正常新陈代谢所必需的营养补充剂。在本研究中，通过各自的斑点试验证实了假种皮、外果皮和内果皮提取物（甲醇提取物）的植物化学筛选。植物化学成分的定量分析表明，与内果皮和果汁相比，外果皮中的总酚含量丰富，而总黄酮和维生素C分别在内果皮和果汁中含量丰富。高效液相色谱、气相色谱以及质谱和傅里叶变换红外光谱分析表明，在外果皮/内果皮中存在化合物9,17-十八碳二烯醛，(Z)。在外果皮中还观察到一种化合物N-十六烷酸。对水果各部分的提取物进行了全面的抗氧化活性评估。与水果假种皮果汁相反，外果皮和内果皮的提取物表现出显著的剂量依赖性抗氧化和自由基清除潜力。提取物（PGEs）的补充显著延长了……的寿命。在……中也观察到PGEs对氧化应激的保护作用。此外，喂食PGEs（外果皮和内果皮）的TJ356蠕虫获得了FOXO同源物DAF-16依赖性长寿的参与。总体而言，结果表明PGEs尤其是外果皮提取物通过其抗氧化特性以及通过依赖胰岛素的信号通路的延长寿命作用，在……的救生机制中发挥着至关重要的作用。另见图1（图1）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/dea7c895bcd8/EXCLI-20-80-g-011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/cdb63ec1894b/EXCLI-20-80-t-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/04439156db57/EXCLI-20-80-t-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/65c9647d4e99/EXCLI-20-80-t-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/291a416aada2/EXCLI-20-80-t-004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/f2480c1e6baa/EXCLI-20-80-g-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/0ba399fe1cfd/EXCLI-20-80-g-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/796dd0b0d586/EXCLI-20-80-g-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/4473eaaf7cf3/EXCLI-20-80-g-004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/f80825e15a20/EXCLI-20-80-g-005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/34ecf810d6e7/EXCLI-20-80-g-006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/b8870a207c9a/EXCLI-20-80-g-007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/6c4ca6288958/EXCLI-20-80-g-008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/8c32a87f373a/EXCLI-20-80-g-009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/0a644e8027dc/EXCLI-20-80-g-010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/dea7c895bcd8/EXCLI-20-80-g-011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/cdb63ec1894b/EXCLI-20-80-t-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/04439156db57/EXCLI-20-80-t-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/65c9647d4e99/EXCLI-20-80-t-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/291a416aada2/EXCLI-20-80-t-004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/f2480c1e6baa/EXCLI-20-80-g-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/0ba399fe1cfd/EXCLI-20-80-g-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/796dd0b0d586/EXCLI-20-80-g-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/4473eaaf7cf3/EXCLI-20-80-g-004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/f80825e15a20/EXCLI-20-80-g-005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/34ecf810d6e7/EXCLI-20-80-g-006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/b8870a207c9a/EXCLI-20-80-g-007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/6c4ca6288958/EXCLI-20-80-g-008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/8c32a87f373a/EXCLI-20-80-g-009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/0a644e8027dc/EXCLI-20-80-g-010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f981/7838930/dea7c895bcd8/EXCLI-20-80-g-011.jpg

相似文献

1
Therapeutic potential of bioactive compounds from Punica granatum extracts against aging and complicity of FOXO orthologue DAF-16 in .石榴提取物中生物活性化合物对衰老的治疗潜力以及FOXO直系同源物DAF-16在……中的协同作用
EXCLI J. 2021 Jan 11;20:80-98. doi: 10.17179/excli2020-3011. eCollection 2021.
2
Glochidion zeylanicum leaf extracts exhibit lifespan extending and oxidative stress resistance properties in Caenorhabditis elegans via DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways.厚鳞柯叶提取物通过 DAF-16/FoxO 和 SKN-1/Nrf-2 信号通路延长秀丽隐杆线虫寿命并增强其抗氧化应激能力。
Phytomedicine. 2019 Nov;64:153061. doi: 10.1016/j.phymed.2019.153061. Epub 2019 Jul 31.
3
In Vitro Evaluation of Biological Activities and Phytochemical Analysis of Different Solvent Extracts of L. (Pomegranate) Peels.石榴皮不同溶剂提取物的生物活性体外评估及植物化学分析
Plants (Basel). 2021 Dec 13;10(12):2742. doi: 10.3390/plants10122742.
4
Chemical analysis of Punica granatum fruit peel and its in vitro and in vivo biological properties.石榴果皮的化学分析及其体外和体内生物学特性。
BMC Complement Altern Med. 2016 Jul 30;16:264. doi: 10.1186/s12906-016-1237-3.
5
A Comprehensive Study of the Antibacterial Activity of Bioactive Juice and Extracts from Pomegranate ( L.) Peels and Seeds.石榴（L.）果皮和种子生物活性汁液及提取物抗菌活性的综合研究
Plants (Basel). 2021 Jul 28;10(8):1554. doi: 10.3390/plants10081554.
6
Comparison of Two Varieties Fig (Peggy Red and Green) Peel Extracts by Liquid Chromatography-Tandem Mass Spectrometry Analysis and for Neuroprotective Efficacy in .通过液相色谱-串联质谱分析比较两种品种无花果（佩吉红和绿色）果皮提取物及其神经保护功效
J Med Food. 2023 Jan;26(1):14-26. doi: 10.1089/jmf.2021.K.0190. Epub 2022 Dec 29.
7
Antimicrobial effect of the Tunisian Nana variety Punica granatum L. extracts against Salmonella enterica (serovars Kentucky and Enteritidis) isolated from chicken meat and phenolic composition of its peel extract.突尼斯娜娜品种石榴（Punica granatum L.）提取物对从鸡肉中分离出的肠炎沙门氏菌（血清型肯塔基和肠炎）的抗菌作用及其果皮提取物的酚类成分。
Int J Food Microbiol. 2017 Jan 16;241:123-131. doi: 10.1016/j.ijfoodmicro.2016.10.007. Epub 2016 Oct 11.
8
Hibiscus sabdariffa L. extract prolongs lifespan and protects against amyloid-β toxicity in Caenorhabditis elegans: involvement of the FoxO and Nrf2 orthologues DAF-16 and SKN-1.玫瑰茄提取物可延长秀丽隐杆线虫的寿命并防止其受到淀粉样-β毒性的影响：涉及 FoxO 和 Nrf2 同源物 DAF-16 和 SKN-1。
Eur J Nutr. 2020 Feb;59(1):137-150. doi: 10.1007/s00394-019-01894-w. Epub 2019 Feb 1.
9
Identification of bioactive phytochemical from two species using GC-MS and estimation of antioxidant activity of seed extracts.利用气相色谱-质谱联用技术从两种植物中鉴定生物活性植物化学物质并评估种子提取物的抗氧化活性。
Saudi J Biol Sci. 2018 Nov;25(7):1420-1428. doi: 10.1016/j.sjbs.2015.11.009. Epub 2015 Nov 26.
10
Antioxidant activity and total phenolic content of ethanolic extract of pomegranate peels, juice and seeds.石榴皮、汁和籽的乙醇提取物的抗氧化活性和总酚含量。
Food Chem Toxicol. 2018 Apr;114:108-111. doi: 10.1016/j.fct.2018.02.023. Epub 2018 Feb 12.

引用本文的文献

1
Peel Waste - An Underutilized Substrate of Therapeutic Potential: An Overview.果皮废料——一种未充分利用的具有治疗潜力的底物：综述
Recent Adv Food Nutr Agric. 2022;13(2):103-119. doi: 10.2174/2772574X14666221124163344.

本文引用的文献

1
DAF-16/FoxO in and Its Role in Metabolic Remodeling.DAF-16/FoxO 在代谢重塑中的作用。
Cells. 2020 Jan 2;9(1):109. doi: 10.3390/cells9010109.
2
Pomegranate Juice and Peel Extracts are Able to Inhibit Proliferation, Migration and Colony Formation of Prostate Cancer Cell Lines and Modulate the Akt/mTOR/S6K Signaling Pathway.石榴汁和果皮提取物能够抑制前列腺癌细胞系的增殖、迁移和集落形成，并调节 Akt/mTOR/S6K 信号通路。
Plant Foods Hum Nutr. 2020 Mar;75(1):54-62. doi: 10.1007/s11130-019-00776-0.
3
Pomegranate juice and extract extended lifespan and reduced intestinal fat deposition in Caenorhabditis elegans.
石榴汁和提取物延长了秀丽隐杆线虫的寿命并减少了其肠道脂肪沉积。
Int J Vitam Nutr Res. 2017 May;87(3-4):149-158. doi: 10.1024/0300-9831/a000570. Epub 2019 Feb 4.
4
Therapeutic potential of cyanobacterial pigment protein phycoerythrin: in silico and in vitro study of BACE1 interaction and in vivo Aβ reduction.蓝藻色素蛋白藻红蛋白的治疗潜力：BACE1 相互作用的计算机模拟和体外研究及体内 Aβ 的减少。
Int J Biol Macromol. 2019 Aug 1;134:368-378. doi: 10.1016/j.ijbiomac.2019.05.006. Epub 2019 May 3.
5
Antioxidant activity and total phenolic content of ethanolic extract of pomegranate peels, juice and seeds.石榴皮、汁和籽的乙醇提取物的抗氧化活性和总酚含量。
Food Chem Toxicol. 2018 Apr;114:108-111. doi: 10.1016/j.fct.2018.02.023. Epub 2018 Feb 12.
6
Phenolic composition of pomegranate peel extracts using an liquid chromatography-mass spectrometry approach with silica hydride columns.采用硅胶柱液相色谱-质谱联用技术分析石榴皮提取物中的酚类成分。
J Sep Sci. 2017 Apr;40(7):1449-1456. doi: 10.1002/jssc.201601310. Epub 2017 Mar 10.
7
Using for aging research.用于衰老研究。
Invertebr Reprod Dev. 2015 Jan 30;59(sup1):59-63. doi: 10.1080/07924259.2014.940470. Epub 2014 Dec 9.
8
Identification of longevity, fertility and growth-promoting properties of pomegranate in Caenorhabditis elegans.在秀丽隐杆线虫中鉴定石榴的长寿、生育力和促进生长特性。
Pharmacogn Mag. 2015 Apr-Jun;11(42):356-9. doi: 10.4103/0973-1296.153089.
9
The lifespan-extending effects of Nymphaea hybrid root extract in the nematode Caenorhabditis elegans.睡莲杂交根提取物对线虫秀丽隐杆线虫的寿命延长作用。
Plant Foods Hum Nutr. 2014 Dec;69(4):304-9. doi: 10.1007/s11130-014-0448-3.
10
Phycoerythrin extends life span and health span of Caenorhabditis elegans.藻红蛋白可延长秀丽隐杆线虫的寿命和健康寿命。
Age (Dordr). 2014;36(5):9717. doi: 10.1007/s11357-014-9717-1. Epub 2014 Oct 11.