Bhadouriya Sneha Lata, Mehrotra Sandhya, Basantani Mahesh K, Loake Gary J, Mehrotra Rajesh
Department of Biological Sciences, Birla Institute of Technology and Sciences, Sancoale, India.
Institute of Bioscience and Technology, Shri Ramswaroop Memorial University, Lucknow, India.
Front Plant Sci. 2021 Jan 12;11:603380. doi: 10.3389/fpls.2020.603380. eCollection 2020.
Sessile plants possess an assembly of signaling pathways that perceive and transmit environmental signals, ultimately resulting in transcriptional reprogramming. Histone is a key feature of chromatin structure. Numerous histone-modifying proteins act under different environmental stress conditions to help modulate gene expression. DNA methylation and histone modification are crucial for genome reprogramming for tissue-specific gene expression and global gene silencing. Different classes of chromatin remodelers including SWI/SNF, ISWI, INO80, and CHD are reported to act upon chromatin in different organisms, under diverse stresses, to convert chromatin from a transcriptionally inactive to a transcriptionally active state. The architecture of chromatin at a given promoter is crucial for determining the transcriptional readout. Further, the connection between somatic memory and chromatin modifications may suggest a mechanistic basis for a stress memory. Studies have suggested that there is a functional connection between changes in nuclear organization and stress conditions. In this review, we discuss the role of chromatin architecture in different stress responses and the current evidence on somatic, intergenerational, and transgenerational stress memory.
固着植物拥有一系列信号通路，这些信号通路能够感知并传递环境信号，最终导致转录重编程。组蛋白是染色质结构的关键特征。众多组蛋白修饰蛋白在不同的环境胁迫条件下起作用，以帮助调节基因表达。DNA甲基化和组蛋白修饰对于组织特异性基因表达和全基因组基因沉默的基因组重编程至关重要。据报道，包括SWI/SNF、ISWI、INO80和CHD在内的不同类型的染色质重塑因子在不同生物体中、在多种胁迫下作用于染色质，将染色质从转录无活性状态转变为转录活性状态。给定启动子处的染色质结构对于确定转录输出至关重要。此外，体细胞记忆与染色质修饰之间的联系可能暗示了应激记忆的机制基础。研究表明，核组织变化与胁迫条件之间存在功能联系。在本综述中，我们讨论了染色质结构在不同应激反应中的作用以及关于体细胞、代际和跨代应激记忆的当前证据。
